R Observatory: Metrics for rxode2 version 5.1.6

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

rxode2

5.1.6

Facilities for Simulating from ODE-Based Models

26packages depend

47.2Kdownloads / year

–test coverage

10/13checks pass

Overview

About

Maintained by Matthew L. FidlerFirst published 2022-05-0933 releasesCRAN page ↗GitHub ↗

Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The 'VODE' and 'LSODA' are in the public domain. The vendored 'SUNDIALS' 'CVODE' sources and headers are released under the BSD-3-Clause license. The information is available in the inst/COPYRIGHTS.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("rxode2", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("nlmixr2/rxode2")

Development version from nlmixr2/rxode2. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-rxode2

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-rxode2

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-rxode2

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

3NOTE10OK

Failing flavors

NOTE r-oldrel-macos-arm64
NOTE r-oldrel-macos-x86_64
NOTE r-oldrel-windows-x86_64

Slowest check: 28.9 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 1.24

not tracked

Coverage

100%

Documentation · exports

22

Dependencies · direct

Check history

NOTE2026-08-12
10 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-08-04
9 OK · 2 NOTE · 0 WARNING · 2 ERROR · 0 FAILURE
NOTE2026-07-28
10 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
WARNING2026-07-27
9 OK · 3 NOTE · 1 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-06-19
10 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Show 8 earlier snapshots

WARNING2026-06-17
10 OK · 2 NOTE · 1 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-06-09
10 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-07
9 OK · 3 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-05-28
11 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-05-02
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-04-22
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
10 OK · 3 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-03-10
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 1,347 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 67% structuredCode of conductNoContributing guideNo

Examples that run: 73%
Documented parameters: 96%
Return-value docs: 99%
References docs: 4%

Downloads

47.2K

CRAN downloads in the past year

Rank #2,112 · ~129/day · ~3.9K/mo

Releases R versions

Daily download trend is not available in this view yet.

3.6K30 days

10.1K90 days

47.2K1 year

Compare downloads with other packages →

Also on1.1K r2u17 autocran20.6K conda_forge38 c2d4u

Repository

GitHub ↗ nlmixr2/rxode2

65Stars

11Forks

85Open issues

8Open PRs

32Releases

10,301Commits

23Contributors

License GPL-3.0 · 10,301 commits · Last activity 2026-08-16 · +4.8% stars, 30d

Stars over time

2025-08-04 · 482026-08-07 · 65

Repository practices

Upstream repositoryBeta

6 development-tooling and community-health practices detected across 5 families in the upstream repository

Checks run against github.com/nlmixr2/rxode2 on 2026-08-16.

Continuous integration (1)

GitHub Actions

CRAN release process (1)

cran-comments.md

Docs source (1)

README.Rmd

Lint, format, editor (1)

lintr

Show all practices

Coverage (2)

Codecov.covrignore

How this is detected·Detection ruleset v1 (2026-07-18)

Development tooling

AI-assisted toolingBeta

Uses AI-assisted development tooling (declared in repo)

Earliest detected marker: copilot on 2025-11-16

copilotclaudegeminiantigravity

Most recent: antigravity on 2026-05-13

Evidence

copilot: on 2025-11-16 · evidence A, D · sole bot-author seen
claude: on 2026-03-01 · evidence A, B, D · sole bot-author seen
gemini: on 2026-05-07 · evidence D
antigravity: on 2026-05-13 · evidence D

How this is detected·Detection ruleset v2 (updated 2026-07-29)

Dependencies

Declared dependencies

67 external dependencies (excludes base and recommended)

Depends (1)

R >= 4.1.0

Imports (22)

PreciseSums Rcpp RcppParallel backports cli checkmate ggplot2 inline lotri memoisemethodsmirai rex systoolsutilsdparser qs2 rxode2ll data.table vctrsstats

LinkingTo (10)

sitmo lotri PreciseSums Rcpp RcppArmadillo BH RcppParallel RcppEigen (>= 0.3.3.9.2)dparser StanHeaders

Enhances (0)

none

Dependency license breakdown →

Code & Tests

Datasets

People & History

People (56)

Maintainer (1)

Matthew L. Fidler

Author, Maintainer

Authors (3)

Matthew L. Fidler

Author, Maintainer

Melissa Hallow

Author

Wenping Wang

Author

Contributors (49)

Morwenn

Contributor

Awad H. Al-Mohy

Contributor

Cody J. Balos

Contributor · added in 5.1.5

Mark M. Baum

Contributor · added in 5.1.3

Peter N. Brown

Contributor · added in 5.1.3

Jim Bunch

Contributor · added in 2.0.9

Scott D. Cohen

Contributor · added in 5.1.5

Aaron Collier

Contributor · added in 5.1.5

Show 41 more contributors

David Cooley

Contributor

Ashley Crawford

Contributor · added in 5.1.5

Bill Denney

Contributor · added in 2.0.12

Jack Dongarra

Contributor

Matt Dowle

Contributor

Omar Elashkar

Contributor · added in 3.0.0

Matteo Fasiolo

Contributor

Yu Feng

Contributor

Rich FitzJohn

Contributor · added in 5.1.3

Simon Frost

Contributor

Goro Fuji

Contributor

David J. Gardner

Contributor · added in 5.1.5

Contributor

Contributor

Contributor

Contributor · added in 5.1.3

Daniel Kaschek

Contributor · added in 5.1.3

Igor Kushnir

Contributor · added in 3.0.0

Michel Lang

Contributor · added in 3.0.2

Contributor

Contributor

Contributor

Contributor · added in 5.1.5

Linda Petzold

Contributor

Thomas Petzoldt

Contributor · added in 5.1.3

Daniel R. Reynolds

Contributor · added in 5.1.5

Drew Schmidt

Contributor

Radu Serban

Contributor · added in 5.1.5

Woodrow Setzer

Contributor · added in 5.1.3

Dan Shumaker

Contributor · added in 5.1.5

Roger B. Sidje

Contributor

Karline Soetaert

Contributor · added in 5.1.3

Arun Srinivasan

Contributor

Gabriel Staples

Contributor · added in 3.0.0

Gilbert Stewart

Contributor · added in 2.0.9

Richard Upton

Contributor · added in 3.0.0

Contributor

Contributor

Contributor

Contributor · added in 5.1.3

Hidde van de Beek

Contributor · added in 5.1.3

Copyright holders (4)

Imperial College of Science, Technology and Medicine

Copyright holder · added in 5.1.3

Lawrence Livermore National Security

Copyright holder · added in 5.1.5

Southern Methodist University

Copyright holder · added in 5.1.5

University of Maryland Baltimore County

Copyright holder · added in 5.1.5

Package Timeline

33 releases. Pick two to compare their code metrics. R releases are shown for context.

5.1.6Latest
2026-08-05 · current release · diff ↗
5.1.5
2026-07-28 · diff ↗
5.1.4
2026-07-21 · diff ↗
5.1.3
2026-07-19 · diff ↗
5.1.2
2026-06-02 · diff ↗
5.1.1
2026-05-28 · diff ↗
R
R 4.6.0 released · 2026-04-24
5.0.2
2026-03-20 · diff ↗
5.0.1
2025-12-09 · diff ↗
5.0.0
2025-11-28 · diff ↗
4.1.1
2025-10-08 · diff ↗
4.1.0
2025-08-29 · diff ↗
4.0.3
2025-07-24 · diff ↗
4.0.2
2025-07-21 · diff ↗
4.0.1
2025-07-18 · diff ↗
4.0.0
2025-07-16 · diff ↗

Show 22 earlier events

R
R 4.5.0 released · 2025-04-11
3.0.4
2025-02-14 · diff ↗
3.0.3
2024-12-15 · diff ↗
3.0.2
2024-10-30 · diff ↗
3.0.1
2024-09-22 · diff ↗
3.0.0
2024-09-18 · diff ↗
2.1.3
2024-05-28 · diff ↗
R
R 4.4.0 released · 2024-04-24
2.1.2
2024-01-31 · diff ↗
2.1.1
2023-12-13 · diff ↗
2.1.0
2023-12-11 · diff ↗
2.0.14
2023-10-07 · diff ↗
2.0.13
2023-04-22 · diff ↗
R
R 4.3.0 released · 2023-04-21
2.0.12
2023-03-28 · diff ↗
2.0.11
2022-11-01 · diff ↗
2.0.10
2022-10-20 · diff ↗
2.0.9
2022-10-19 · diff ↗
2.0.8
2022-09-23 · diff ↗
2.0.7
2022-09-23 · diff ↗
2.0.6
2022-05-09
R
R 4.2.0 released · 2022-04-22

Package metadata

First published: 2022-05-09
Total releases: 33 / 4 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.1.0
Bundled data: 5.1 KB / 3 files
Download size: 4.4 MB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Differential Equations High-Performance and Parallel Computing with R Mixed, Multilevel, and Hierarchical Models in R Analysis of Pharmacokinetic Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("rxode2")

Format

Fidler, M. L., Imperial College of Science, Technology and Medicine, Lawrence Livermore National Security, Morwenn, Southern Methodist University, University of Maryland Baltimore County, Al-Mohy, A. H., Balos, C. J., Baum, M. M., Brown, P. N., Bunch, J., Cohen, S. D., Collier, A., Cooley, D., Crawford, A., Denney, B., Dongarra, J., Dowle, M., Elashkar, O., Fasiolo, M., Feng, Y., FitzJohn, R., Frost, S., Fuji, G., Gardner, D. J., Hairer, E., Hallow, M., Higham, N. J., Hindmarsh, A., Hinsley, W., Kaschek, D., Kushnir, I., Lang, M., Maechler, M., Moler, C., Mulyukov, Z., Peles, S., Petzold, L., Petzoldt, T., Reynolds, D. R., Schmidt, D., Serban, R., Setzer, W., Shumaker, D., Sidje, R. B., Soetaert, K., Srinivasan, A., Staples, G., Stewart, G., Upton, R., Ushey, K., Wang, W., Wanner, G., Wickham, H., Williams, J., & van de Beek, H. (2026). rxode2: Facilities for Simulating from ODE-Based Models (Version 5.1.6) [Computer software]. https://doi.org/10.32614/CRAN.package.rxode2

This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for rxode2 version 5.1.6 [Data set]. HJJB, LLC. Data release v2026-08-16. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-16, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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