R Observatory: Metrics for nlmixr2autoinit version 1.0.1

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

nlmixr2autoinit

1.0.1

Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling

2packages depend

2.3Kdownloads / year

–test coverage

13/13checks pass

Overview

About

Maintained by Zhonghui HuangFirst published 2025-11-132 releasesCRAN page ↗GitHub ↗

Provides automated methods for generating initial parameter estimates in population pharmacokinetic modeling. The pipeline integrates adaptive single-point methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter sweeping across pharmacokinetic models. It estimates residual unexplained variability using either data-driven or fixed-fraction approaches and assigns pragmatic initial values for inter-individual variability. These strategies are designed to improve model robustness and convergence in 'nlmixr2' workflows. For more details see Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) doi:10.1007/s10928-025-10000-z.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)

install.packages("nlmixr2autoinit", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("ucl-pharmacometrics/nlmixr2autoinit")

Development version from ucl-pharmacometrics/nlmixr2autoinit. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-nlmixr2autoinit

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-nlmixr2autoinit

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

13OK

Slowest check: 3.9 min · r-oldrel-windows-x86_64

Code health

None

Tests · ratio 0.00

not tracked

Coverage

100%

Documentation · exports

13

Dependencies · direct

Check history

OK2026-08-12
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-08-04
10 OK · 1 NOTE · 0 WARNING · 2 ERROR · 0 FAILURE
NOTE2026-08-01
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-06-09
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE

Show 1 earlier snapshots

OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesNopkgdown siteNoNEWSNoCode of conductNoContributing guideNo

Examples that run: 75%
Documented parameters: 98%
Return-value docs: 100%
References docs: 2%

Downloads

2.3K

CRAN downloads in the past year

Rank #11,560 · ~6/day · ~195/mo

Releases R versions

Daily download trend is not available in this view yet.

37030 days

85490 days

2.3K1 year

Compare downloads with other packages →

Also on72 r2u

Repository

GitHub ↗ ucl-pharmacometrics/nlmixr2autoinit

Repository practices

Upstream repositoryBeta

Repository github.com/ucl-pharmacometrics/nlmixr2autoinit is linked, but repository-practices checks have not run for it yet.

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

13 external dependencies (excludes base and recommended)

Depends (2)

R >= 4.0nlmixr2data

Imports (12)

nlmixr2 nlmixr2est rxode2 dplyr tidyr crayon purrr knitr magrittr progressr tibble vpc

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

2direct

0indirect

nlmixr2auto nlmixr2

Code & Tests

People & History

People (4)

Maintainer (1)

Zhonghui Huang

Author, Maintainer

Authors (1)

Zhonghui Huang

Author, Maintainer

Contributors (3)

Matthew Fidler

Contributor

Frank Kloprogge

Contributor

Joseph Standing

Contributor

Package Timeline

2 releases. Pick two to compare their code metrics. R releases are shown for context.

1.0.1Latest
2026-06-09 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
1.0.0
2026-03-10
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-11-13
Total releases: 2 / 1 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.0
Download size: 91 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("nlmixr2autoinit")

Format

Huang, Z., Fidler, M., Kloprogge, F., & Standing, J. (2026). nlmixr2autoinit: Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling (Version 1.0.1) [Computer software]. https://doi.org/10.32614/CRAN.package.nlmixr2autoinit

This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for nlmixr2autoinit version 1.0.1 [Data set]. HJJB, LLC. Data release v2026-08-16. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-16, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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