R Observatory: Metrics for admixr2 version 0.2.0

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

admixr2

0.2.0

Aggregate Data Modelling

1packages depend

1.5Kdownloads / year

81.7%test coverage

13/13checks pass

Overview

About

Maintained by H. van de BeekFirst published 2026-06-022 releasesCRAN page ↗GitHub ↗

Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the 'nlmixr2'/'rxode2' ecosystem via four estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH') estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) doi:10.1007/s10928-021-09760-1; software described in van de Beek et al. (2025) doi:10.1007/s10928-025-10011-w.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)

install.packages("admixr2", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("LeidenPharmacology/admixr2")

Development version from LeidenPharmacology/admixr2. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-admixr2

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-admixr2

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

13OK

Slowest check: 8.5 min · r-oldrel-windows-x86_64

Code health

Yes

Tests · ratio 0.95

81.7%

Coverage · measured lines

100%

Documentation · exports

8

Dependencies · direct

Check history

OK2026-08-12
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-08-04
10 OK · 1 NOTE · 0 WARNING · 2 ERROR · 0 FAILURE
NOTE2026-08-01
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-06-09
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-06-08
12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE

Show 1 earlier snapshots

OK2026-06-03
6 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 527 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: 73%
Documented parameters: 82%
Return-value docs: 100%
References docs: 0%

Downloads

1.5K

CRAN downloads in the past year

Rank #5,232 · ~4/day · ~122/mo

Releases R versions

Daily download trend is not available in this view yet.

48830 days

1.5K90 days

1.5K1 year

Compare downloads with other packages →

Also on63 r2u

Repository

GitHub ↗ leidenpharmacology/admixr2

2Stars

1Forks

8Open issues

1Open PRs

0Releases

300Commits

3Contributors

meta-analysispharmacodynamicspharmacokineticspharmacometrics

300 commits · Last activity 2026-08-21 · +100% stars, 30d

Stars over time

2026-06-12 · 12026-08-15 · 2

Repository practices

Upstream repositoryBeta

5 development-tooling and community-health practices detected across 4 families in the upstream repository

Checks run against github.com/leidenpharmacology/admixr2 on 2026-08-16.

Continuous integration (1)

GitHub Actions

CRAN release process (2)

cran-comments.mdCRAN-SUBMISSION

Lint, format, editor (1)

RStudio project

Coverage (1)

.covrignore

How this is detected·Detection ruleset v1 (2026-07-18)

Development tooling

AI-assisted toolingBeta

Uses AI-assisted development tooling (declared in repo)

Earliest detected marker: claude on 2026-05-29

claude

Most recent: claude on 2026-05-29

Evidence

claude: on or before 2026-05-29 · evidence B, D

How this is detected·Detection ruleset v2 (updated 2026-07-29)

Dependencies

Declared dependencies

20 external dependencies (excludes base and recommended)

Depends (1)

R >= 4.1.0

Imports (8)

checkmate digest nlmixr2est nloptr qs2 randtoolbox Rcpp rxode2

LinkingTo (2)

Rcpp RcppEigen

Suggests (10)

expm furrr future ggplot2 knitr mnormt nlmixr2 (>= 5.0.0)patchwork rmarkdown testthat

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

1direct

0indirect

nlmixr2

Code & Tests

Datasets

People & History

People (4)

Maintainer (1)

H. van de Beek

Author, Maintainer

Authors (4)

Author, Maintainer

Author

Author

Author

Package Timeline

2 releases. Pick two to compare their code metrics. R releases are shown for context.

0.2.0Latest
2026-07-03 · current release · diff ↗
0.1.0
2026-06-02
R
R 4.6.0 released · 2026-04-24

Package metadata

First published: 2026-06-02
Total releases: 2 / 1 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.1.0
Bundled data: 13 KB / 1 file
Download size: 293 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("admixr2")

Format

van de Beek, H., Välitalo, P. A. J., Zwep, L. B., & van Hasselt, J. G. C. (2026). admixr2: Aggregate Data Modelling (Version 0.2.0) [Computer software]. https://doi.org/10.32614/CRAN.package.admixr2

This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for admixr2 version 0.2.0 [Data set]. HJJB, LLC. Data release v2026-08-22. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-22, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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