PKPD, PBPK, and Systems Pharmacology Modeling Tools
Overview
Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable 'Shiny' app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with 'PowerPoint' and 'Word'.
Notes
- Removed the NONMEM and Monolix outputs
- Added translation of nlmixr2 output into NONMEM and Monolix outputs
- Added simulation option
dynamicset toTRUEby default and when set toFALSEit will fix ODEs to 0 and allow for in vitro analysis. - Applying
<OE:?>to variance models in cohort definitions. - Fixed issue where initial conditions were not being passed to nlmixr2 output.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-04
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- WARNING12 OK, 1 WARNING2026-06-07
Show 2 earlier changesHide 2 earlier changes
- OK12 OK2026-04-25
- NOTE11 OK, 3 NOTE2026-03-10
Documentation
- Help pages
- 98 (29 internal)
- Examples that run
- 41%13 run in a plain check · 19 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 39%
- Documented parameters
- 98%
- Return-value docs
- 100%
- Help pages citing references
- 0%
- Deployment HTML
- Estimation HTML
- Language HTML
- Report Generation HTML
- Simulation HTML
- Titration/Rule-Based Simulations HTML
Downloads
Repository
- PRs merged (all time)
- 0%
- Median days to close, 50 most recently updated closed issues
- 178
- Median days to close, 50 most recently updated closed PRs
- 1
Stars over time
Forks over time
Releases over time
Issues over time
PRs over time
5 development-tooling and community-health practices detected across 3 families in the upstream repository
Checks run against github.com/john-harrold/ubiquity on 2026-10-21.
The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel
Dependencies
Installing ubiquity adds 97 packages (48 with compiled code, 90 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, data.table 5.7 MB.
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- 2.1.0Latest
- RR 4.4.0 released · 2024-04-24
- 2.0.32024-03-08 · diff ↗
- 2.0.12023-10-29 · diff ↗
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- 2.0.02021-09-03 · diff ↗ ·
removed 20 exports
md_to_officer, md_to_oo, system_fetch_report, system_fetch_report_format, system_glp_save, system_report_doc_add_content, system_report_doc_format_section, system_report_doc_set_ph, system_report_estimation, system_report_glp, system_report_init, system_report_nca, system_report_ph_content, system_report_save, system_report_set, system_report_slide_content, system_report_slide_section, system_report_slide_title, system_report_slide_two_col, system_report_view_layoutadded 11 exports
system_fetch_rpt_officer_object, system_fetch_rpt_onbrand_object, system_rpt_add_doc_content, system_rpt_add_slide, system_rpt_estimation, system_rpt_nca, system_rpt_read_template, system_rpt_save_report, system_rpt_template_details, system_set_rpt_officer_object, system_set_rpt_onbrand_object - RR 4.1.0 released · 2021-05-18
- 1.0.5
- 1.0.42021-04-18 · diff ↗ ·
removed 3 exports
system_report_fetch, tic, tocadded 7 exports
md_to_oo, system_fetch_nca, system_fetch_nca_columns, system_fetch_report, system_fetch_report_format, system_nca_parameters_meta, system_nca_summary - 1.0.3
- 1.0.2
- RR 4.0.0 released · 2020-04-24
- 1.0.1
Show 2 earlier eventsHide 2 earlier events
- 1.0.02019-10-17
- RR 3.6.0 released · 2019-04-26
Package metadata
- First published
- 2019-10-17
- Total releases
- 10 / 7 yrs
- License
- BSD_2_clause + file LICENSE OSI
- Minimum R
- ≥ 4.2.0
- Download size
- 3.4 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("ubiquity")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1007/s10928-014-9352-6.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-23, which the citation names so these numbers can be found later. More on citing and the projects behind them.