R Observatory: Metrics for nlmixr2 version 7.0.1

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

nlmixr2

7.0.1Package record

Nonlinear Mixed Effects Models in Population PK/PD

2packages dependsuggested by 7

19.2Kdownloads / year

45.3%test coverage

13/13flavors OK

Overview

About

Maintained by Matthew FidlerCRAN page ↗GitHub ↗Website ↗Issues ↗

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 doi:10.1007/s10928-015-9409-1). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 doi:10.1002/psp4.12052).

Changes in 7.0.1

nlmixr2CheckInstall() no longer fails when the repositories cannot be queried for package updates. Both an unreachable repository and an error from utils::old.packages() itself (seen on Windows, where pkgType is "both" and R's internal .available.both() can fail with "subscript out of bounds" when the source and binary indexes disagree) are now reported as "updates could not be checked" instead of stopping the check.
nlmixr2CheckInstall() messages are escaped before they are handed to cli, so paths or command output containing { or } are shown literally rather than being interpreted as glue expressions.

From NEWS.md in the release

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)

install.packages("nlmixr2", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("nlmixr2/nlmixr2")

Development version from nlmixr2/nlmixr2. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-nlmixr2

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-nlmixr2

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 3.0 min · r-oldrel-windows-x86_64

Status changes

OK13 OK2026-10-03
ERROR11 OK, 2 ERROR2026-09-12
OK13 OK2026-08-12
ERROR10 OK, 1 NOTE, 2 ERROR2026-08-04
NOTE12 OK, 1 NOTE2026-08-01

Show 27 earlier changesHide 27 earlier changes

OK13 OK2026-07-23
ERROR12 OK, 1 ERROR2026-07-21
OK13 OK2026-07-18
ERROR12 OK, 1 ERROR2026-07-14
OK13 OK2026-07-13
ERROR12 OK, 1 ERROR2026-07-10
OK13 OK2026-07-07
ERROR12 OK, 1 ERROR2026-06-30
OK13 OK2026-06-29
ERROR12 OK, 1 ERROR2026-06-25
OK13 OK2026-06-24
ERROR12 OK, 1 ERROR2026-06-16
OK13 OK2026-06-15
ERROR12 OK, 1 ERROR2026-06-11
OK13 OK2026-06-09
ERROR11 OK, 2 ERROR2026-06-08
OK13 OK2026-06-06
ERROR12 OK, 1 ERROR2026-06-01
OK13 OK2026-05-29
ERROR12 OK, 1 ERROR2026-05-27
OK13 OK2026-05-10
ERROR12 OK, 1 ERROR2026-05-08
OK13 OK2026-05-04
ERROR12 OK, 1 ERROR2026-04-28
OK14 OK2026-04-22
ERROR13 OK, 1 ERROR2026-04-15
OK14 OK2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 7.0.1

READMEYes · 591 wordsVignettes· In the repository, left out of the releaseNEWSYes · 100% structured · mentions 7.0.1Citation fileYes · cites a publicationWebsiteYes · pkgdown

The repository also keeps web-only articles.

Help pages: 6 (1 internal)
Examples that run: 75%3 run in a plain check · 1 never run
Exported functions with examples: 67%
Documented parameters: 100%
Return-value docs: 33%
Help pages citing references: 0%

How these are measured

Downloads

19.2K

CRAN downloads in the past year

Rank #2,886 · ~53/day · ~1.6K/mo

Releases R versions

Daily download trend is not available in this view yet.

1.7K30 days

5K90 days

19.2K1 year

Compare downloads with other packages →

Also on506 r2u18.8K conda_forge85 c2d4u

How downloads are counted

Repository

nlmixr2/nlmixr2 ↗Organization: nlmixr2

103Stars

7Forks

48Open issues

4Open PRs

14Releases

473Commits

6Commit identities

License file reads as GPL-3.0 · 473 commits · Last activity 2026-09-18 · +3% stars, 30d · Discussions: 124 posts

Responsiveness

How these are sampled

PRs merged (all time): 87%
Median days to close, 50 most recently updated closed issues: 2
Median days to close, 50 most recently updated closed PRs: 0

Stars over time

2026-07-14 · 932026-10-23 · 103

How these are measured

PracticesBeta

8 development-tooling and community-health practices detected across 4 families in the upstream repository

Checks run against github.com/nlmixr2/nlmixr2 on 2026-10-22.

Continuous integration (2)

GitHub ActionsR CMD check workflow

The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel

Docs source (4)

README.Rmdpkgdown

GitHub Pages site last deployed 2026-10-20 · The repository has a site deploy workflow

Coverage (1)

Coverage reporting (Codecov)

CRAN release process (1)

cran-comments.md

How this is detected·Detection ruleset v4 (2026-10-20)

AI coding toolsBeta

This repository shows signs of AI coding tools.

Claude Codefirst seen 2026-07-08
Seen in the repository: CLAUDE.md
Named in .Rbuildignore: CLAUDE.md
Pull request it wrote: opened by a project member
Commits: at least 64 crediting it in the message

Models named in its commits

Claude Opus 4.829 commits · Jul 2026
Claude Opus 527 commits · Jul to Aug 2026
Claude Fable 58 commits · Jul 2026

Counts are commits, not lines of code. Commits by a tool's accounts count once across all of its accounts. Commits crediting it are the largest count among its credit lines, a minimum.How this is detected·Detection ruleset v4 (updated 2026-09-27)

Dependencies

Declared dependencies

35 external dependencies (excludes base and recommended)

Installing nlmixr2 adds 140 packages (89 with compiled code, 113 MB of source tarballs). Heaviest: BH 14 MB, stringi 11 MB, ggplot2 6.0 MB.

Depends (1)

R >= 4.1.0

Imports (13)

clisymbols cli crayon dplyr (>= 0.7.4)purrr rstudioapi nlmixr2est (>= 5.0.0)nlmixr2extra rxode2 lotri (>= 0.4.3)nlmixr2plot tibble nlmixr2save

LinkingTo (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

2direct

0indirect

Imports 2

Suggested by 7

Depends, Imports or LinkingTo, most downloaded first

nlmixr2auto nlmixr2autoinit

Suggests, most downloaded first

tidyvpc admixr2 xpose.nlmixr2 pmxNODE shinyMixR ruminate xpose.xtras

How these are counted

Code & Tests

People & History

People (11)

Matthew Fidler

Author, Maintainer since 2.0.6 (2022)

Bill Denney

Contributor

John Harrold

Contributor

Richard Hooijmaijers

Contributor

Michael Wayne Kearney

Contributor · added in 4.0.0

Anne Keunecke

Contributor · added in 3.0.2

Theodoros Papathanasiou

Contributor

Rik Schoemaker

Contributor

Mirjam Trame

Contributor

Show 2 more contributorsHide 2 contributors

Wenping Wang

Contributor

Justin Wilkins

Contributor

Listed in earlier versions (3)

Show 3 peopleHide 3 people

Teun Post

no longer listed · 2.0.6 to 3.0.1

Yuan Xiong

no longer listed · 2.0.6 to 3.0.1

Huijuan Xu

no longer listed · 2.0.6 to 3.0.1

Releases (14)

Pick two releases to compare their code metrics.

7.0.1Latest
record
2026-08-05 · current release · diff ↗
R
R 4.6.0 released · 2026-04-24
5.0.0
record
2025-11-30 · diff ↗
4.0.1
record
2025-08-29 · diff ↗
4.0.0
record
2025-07-17 · diff ↗ ·
removed 97 exports
%>%, ini<-, model<-, .nlmixrNlmeFun, ACF, RxODE, VarCorr, add.dosing, add.sampling, addCwres, addNpde, addTable, augPred, bobyqaControl, bootplot, bootstrapFit, et, etExpand, eventTable, expit, fixed.effects, fixef, foceiControl, geom_amt, geom_cens, getData, getVarCov, groupedData, ini, lbfgsb3cControl and 67 more

added 5 exports
.nlmixr2attach, nlmixr2conflicts, nlmixr2deps, nlmixr2packages, nlmixr2update
R
R 4.5.0 released · 2025-04-11
3.0.2
record
2025-02-20 · diff ↗ ·
added 1 export
rxSetSeed
3.0.1
record
2024-10-28 · diff ↗ ·
removed 1 export
covarSearchAuto
3.0.0
record
2024-09-18 · diff ↗ ·
added 3 exports
profileFixed, profileFixedSingle, profileLlp
2.1.2
record
2024-05-30 · diff ↗ ·
added 9 exports
bobyqaControl, lbfgsb3cControl, n1qn1Control, newuoaControl, nlmControl, nlminbControl, nlsControl, optimControl, uobyqaControl
R
R 4.4.0 released · 2024-04-24
2.1.1
record
2024-02-01 · diff ↗
2.1.0
record
2024-01-09 · diff ↗ ·
added 6 exports
ini<-, model<-, etExpand, nlmixr2AllEst, rxFun, rxSetPipingAuto
R
R 4.3.0 released · 2023-04-21
2.0.9
record
2023-02-21 · diff ↗ ·
added 2 exports
nlmixr2CheckInstall, rxDerived
2.0.8
record
2022-10-23 · diff ↗ ·
added 3 exports
vpcCens, vpcCensTad, vpcPlotTad

Show 3 earlier eventsHide 3 earlier events

2.0.7
record
2022-06-28 · diff ↗ ·
added 1 export
logit
2.0.6
record
2022-05-24
R
R 4.2.0 released · 2022-04-22

Package metadata

First published: 2022-05-24
Total releases: 14 / 4 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.1.0
Download size: 1.1 MB

Appears in task views

Differential Equations High-Performance and Parallel Computing with R Mixed, Multilevel, and Hierarchical Models in R Analysis of Pharmacokinetic Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("nlmixr2")

The package provides a citation file that builds its entry when R runs it. Run citation() to see it.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for nlmixr2 version 7.0.1 [Data set]. HJJB, LLC. Data release v2026-10-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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