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nlmixr2

Nonlinear Mixed Effects Models in Population PK/PD

v5.0.0 · Nov 29, 2025 · GPL (>= 3)

Description

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

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CRAN Check Status

14 OK
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Flavor Status
r-devel-linux-x86_64-debian-clang OK
r-devel-linux-x86_64-debian-gcc OK
r-devel-linux-x86_64-fedora-clang OK
r-devel-linux-x86_64-fedora-gcc OK
r-devel-macos-arm64 OK
r-devel-windows-x86_64 OK
r-oldrel-macos-arm64 OK
r-oldrel-macos-x86_64 OK
r-oldrel-windows-x86_64 OK
r-patched-linux-x86_64 OK
r-release-linux-x86_64 OK
r-release-macos-arm64 OK
r-release-macos-x86_64 OK
r-release-windows-x86_64 OK

Check History

OK 14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026

Reverse Dependencies (8)

Dependency Network

Dependencies Reverse dependencies cli crayon dplyr purrr (>= 0.2.4) rstudioapi nlmixr2est nlmixr2extra rxode2 lotri nlmixr2plot tibble magrittr nlmixr2auto nlmixr2autoinit pmxNODE ruminate shinyMixR tidyvpc xpose.nlmixr2 xpose.xtras nlmixr2

Version History

new 5.0.0 Mar 10, 2026
updated 5.0.0 ← 4.0.1 diff Nov 29, 2025
updated 4.0.1 ← 4.0.0 diff Aug 28, 2025
updated 4.0.0 ← 3.0.2 diff Jul 16, 2025
updated 3.0.2 ← 3.0.1 diff Feb 19, 2025
updated 3.0.1 ← 3.0.0 diff Oct 27, 2024
updated 3.0.0 ← 2.1.2 diff Sep 17, 2024
updated 2.1.2 ← 2.1.1 diff May 29, 2024
updated 2.1.1 ← 2.1.0 diff Jan 31, 2024
updated 2.1.0 ← 2.0.9 diff Jan 8, 2024
updated 2.0.9 ← 2.0.8 diff Feb 20, 2023
updated 2.0.8 ← 2.0.7 diff Oct 22, 2022
updated 2.0.7 ← 2.0.6 diff Jun 27, 2022
new 2.0.6 May 23, 2022