nlmixr2est

6.0.1

Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

15packages depend

25.3Kdownloads / year

–test coverage

13/13checks pass

Overview

About

Maintained by Matthew FidlerFirst published 2022-05-1228 releasesCRAN page ↗GitHub ↗

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 doi:10.1007/s10928-015-9409-1). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 doi:10.1002/psp4.12052).

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)

install.packages("nlmixr2est", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("nlmixr2/nlmixr2est")

Development version from nlmixr2/nlmixr2est. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-nlmixr2est

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-nlmixr2est

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

Health

CRAN checks

13OK

Slowest check: 14.5 min · r-devel-linux-x86_64-fedora-gcc

Code health

Yes

Tests · ratio 0.39

not tracked

Coverage

100%

Documentation · exports

None

Vignettes

README

Dependencies · direct

Check history

OK2026-04-25
12 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-04-22
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-18
11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
NOTE2026-03-10
11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Downloads

25.3K

CRAN downloads in the past year

Rank #2,957 · ~69/day · ~2.1K/mo

Releases R versions

Daily download trend is not available in this view yet.

1.7K30 days

5.4K90 days

25.3K1 year

Compare downloads with other packages →

Also on898 r2u17K conda_forge38 c2d4u

Repository

GitHub ↗ nlmixr2/nlmixr2est

Dependencies

Declared dependencies

41 external dependencies (excludes base and recommended)

Depends (2)

R >= 4.1.0nlmixr2data

Imports (18)

backports checkmate cligraphicsknitr lbfgsb3c lotriMatrixmethodsminqa n1qn1nlmeRcpp rex rxode2statssymengineutils

LinkingTo (8)

BH n1qn1 lbfgsb3c lotri (>= 0.5.0)Rcpp RcppArmadillo RcppEigen rxode2

Suggests (20)

broom.mixed crayon data.table devtools digest dplyr (>= 1.1.0)generics nloptr qs2 sys testthat tibble withr xgxr sfsmisc minpack.lm remotes fastGHQuad rmarkdown rlang

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

15direct

0indirect

admixr2 babelmixr2 nlmixr2 nlmixr2auto nlmixr2autoinit nlmixr2extra nlmixr2lib nlmixr2plot nlmixr2rpt nlmixr2targets shinyMixR xpose.nlmixr2 ggPMX nlmixr2save xpose.xtras

Code & Tests

Code Composition

R 38,884 (58%)C++ 14,762 (22%)Rd 10,881 (16%)C 2,227 (3%)Markdown 50 (0%)Vignettes 6 (0%)

Code characteristics

Object systems

S3398

Cyclomatic complexity: 2.0 median / 78 max
Test cases: 257 / 0.39 per code line
Documented parameters: 99%

Test coverage

Line coverage

–

Expression

–

Tests / Examples

–

Functions

1171 138 exported

Complexity

3.5 avg / 78 max

Call network

1171 nodes / 1174 edges

Call graph

Open call graph →

Loading call graph…

Lowest coverage

Per-function coverage is not measured for this package yet.

People & History

People (24)

Maintainer (1)

Matthew Fidler

Author, Maintainer

Authors (7)

Author, Maintainer

Author

Author

Author

Author

Author

Author

Contributors (14)

Mahmoud Abdelwahab

Contributor

Hajar Besbassi

Contributor · added in 6.0.0

Contributor

Contributor

Contributor

Contributor

Contributor

Contributor

Show 6 more contributors

Contributor

Contributor

Contributor

Contributor

Contributor

Contributor

Package Timeline

28 releases. Pick two to compare their code metrics. R releases are shown for context.

6.0.1Latest
2026-06-03 · current release · diff ↗
6.0.0
2026-05-31 · diff ↗
R
R 4.6.0 released · 2026-04-24
5.0.2
2025-11-28 · diff ↗
4.1.1
2025-10-09 · diff ↗
4.1.0
2025-08-29 · diff ↗
4.0.2
2025-07-25 · diff ↗
4.0.1
2025-07-20 · diff ↗
4.0.0
2025-07-16 · diff ↗
R
R 4.5.0 released · 2025-04-11
3.0.4
2025-02-19 · diff ↗
3.0.3
2025-01-18 · diff ↗
3.0.2
2024-11-23 · diff ↗
3.0.1
2024-10-23 · diff ↗
3.0.0
2024-09-18 · diff ↗
2.2.2
2024-05-28 · diff ↗

Show 17 earlier events

R
R 4.4.0 released · 2024-04-24
2.2.1
2024-01-31 · diff ↗
2.2.0
2023-12-12 · diff ↗
2.1.8
2023-10-08 · diff ↗
2.1.7
2023-09-19 · diff ↗
2.1.6
2023-05-26 · diff ↗
2.1.5
2023-04-22 · diff ↗
R
R 4.3.0 released · 2023-04-21
2.1.4
2023-04-02 · diff ↗
2.1.3
2022-11-10 · diff ↗
2.1.2
2022-11-02 · diff ↗
2.1.1
2022-10-22 · diff ↗
2.1.0
2022-10-19 · diff ↗
2.0.8
2022-06-22 · diff ↗
2.0.7
2022-05-23 · diff ↗
2.0.6
2022-05-12
R
R 4.2.0 released · 2022-04-22

Package metadata

First published: 2022-05-12
Total releases: 28 / 4 yrs
License: GPL (>= 3) OSI
Minimum R: ≥ 4.1.0
Bundled data: 2.3 KB / 1 file
Download size: 1.1 MB
Installed size: not tracked yet
With dependencies: not tracked yet

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