nlmixr2est
Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines
v5.0.2
·
Nov 28, 2025
·
GPL (>= 3)
Description
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
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CRAN Check Status
6
NOTE
8
OK
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | NOTE |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | NOTE |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (6 non-OK)
NOTE
r-devel-linux-x86_64-debian-clang
compiled code
File ‘nlmixr2est/libs/nlmixr2est.so’: Found non-API call to R: ‘R_UnboundValue’ Compiled code should not call non-API entry points in R. See ‘Writing portable packages’ in the ‘Writing R Extensions’ manual, and section ‘Moving into C API compliance’ for issues with the use of non-API entry points.
NOTE
r-devel-linux-x86_64-debian-gcc
compiled code
File ‘nlmixr2est/libs/nlmixr2est.so’: Found non-API call to R: ‘R_UnboundValue’ Compiled code should not call non-API entry points in R. See ‘Writing portable packages’ in the ‘Writing R Extensions’ manual, and section ‘Moving into C API compliance’ for issues with the use of non-API entry points.
NOTE
r-devel-windows-x86_64
compiled code
File 'nlmixr2est/libs/x64/nlmixr2est.dll': Found non-API call to R: 'R_UnboundValue' Compiled code should not call non-API entry points in R. See 'Writing portable packages' in the 'Writing R Extensions' manual, and section 'Moving into C API compliance' for issues with the use of non-API entry points.
NOTE
r-oldrel-macos-arm64
installed package size
installed size is 22.1Mb
sub-directories of 1Mb or more:
R 2.0Mb
libs 18.9Mb
NOTE
r-oldrel-macos-x86_64
installed package size
installed size is 22.3Mb
sub-directories of 1Mb or more:
R 2.0Mb
libs 19.1Mb
NOTE
r-patched-linux-x86_64
compiled code
File ‘nlmixr2est/libs/nlmixr2est.so’: Found non-API call to R: ‘R_UnboundValue’ Compiled code should not call non-API entry points in R. See ‘Writing portable packages’ in the ‘Writing R Extensions’ manual, and section ‘Moving into C API compliance’ for issues with the use of non-API entry points.
Additional Issues
donttest
Details →
Check History
NOTE 11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
NOTE
r-devel-macos-arm64
compiled code
File ‘nlmixr2est/libs/nlmixr2est.so’: Found non-API call to R: ‘ATTRIB’ Compiled code should not call non-API entry points in R. See ‘Writing portable packages’ in the ‘Writing R Extensions’ manual, and section ‘Moving into C API compliance’ for issues with the use of non-API entry points.
NOTE
r-oldrel-macos-arm64
installed package size
installed size is 22.1Mb
sub-directories of 1Mb or more:
R 2.0Mb
libs 18.9Mb
NOTE
r-oldrel-macos-x86_64
installed package size
installed size is 22.3Mb
sub-directories of 1Mb or more:
R 2.0Mb
libs 19.1Mb
Reverse Dependencies (12)
imports
suggests
Dependency Network
Version History
new
5.0.2
Mar 10, 2026