Immunoglobulin Clonal Lineage and Diversity Analysis
Overview
Provides methods for high-throughput adaptive immune receptor repertoire sequencing (AIRR-Seq; Rep-Seq) analysis. In particular, immunoglobulin (Ig) sequence lineage reconstruction, lineage topology analysis, diversity profiling, amino acid property analysis and gene usage. Citations: Gupta and Vander Heiden, et al (2017) doi:10.1093/bioinformatics/btv359, Stern, Yaari and Vander Heiden, et al (2014) doi:10.1126/scitranslmed.3008879.
Sequence:
- Added
fastDist, a faster calculation of pairwise Hamming distances for DNA sequences of equal length containing only the charactersACTGN?. - Added
fastDistAA, a faster calculation of pairwise distances for amino acid sequences of equal length. - Added
seqMismatchCount,seqMismatchMatrixandseqMismatchPositionsto count, tabulate and locate mismatches between sample and germline sequences. - Added the
fieldsargument tocollapseDuplicates, specifying columns (e.g.c_call) whose values must match for sequences to be collapsed together. - Fixed the
ignoreargument ofcollapseDuplicates, which was never used. Sequence equality was always tested with the defaultc("N", "-", ".", "?").
Show all changes in 1.5.0Hide the rest of the changes in 1.5.0
- Added the
ignoreargument topairwiseEqual, which previously always used theseqEqualdefault ofc("N", "-", ".", "?").
From NEWS.md in the release
Install
Health
- OK13 OK2026-09-08
- ERROR12 OK, 1 ERROR2026-09-07
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
Show 6 earlier changesHide 6 earlier changes
- ERROR12 OK, 1 ERROR2026-06-08
- OK13 OK2026-05-10
- ERROR12 OK, 1 ERROR2026-05-03
- OK12 OK2026-04-25
- ERROR13 OK, 1 ERROR2026-03-30
- OK14 OK2026-03-10
Documentation
- Help pages
- 84 (1 internal)includes a package overview page
- Examples that run
- 79%53 run in a plain check · 4 only when donttest examples are enabled (R CMD check --as-cran) · 10 never run
- Exported functions with examples
- 93%
- Documented parameters
- 98%
- Return-value docs
- 92%
- Help pages citing references
- 30%
Downloads
Repository
- PRs merged (all time)
- 88%
- Median days to close, 50 most recently updated closed issues
- 58
- Median days to close, 50 most recently updated closed PRs
- 1
Stars over time
Forks over time
Issues over time
PRs over time
Commits over time
Commit identities over time
7 development-tooling and community-health practices detected across 3 families in the upstream repository
Checks run against github.com/immcantation/alakazam on 2026-10-21.
The R CMD check workflow runs on Linux
This repository shows signs of AI coding tools.
- GitHub Copilotfirst seen 2025-09-30Pull request: opened by its own accountCommits: 2 by its own account
Dependencies
Installing alakazam adds 52 packages (30 with compiled code, 52 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, igraph 4.8 MB. 3 more not on CRAN are not measured.
Code & Tests
Datasets
People & History
Previously maintained by Jason Vander Heiden (0.2.2 to 1.2.1).
Pick two releases to compare their code metrics.
- 1.5.0Latest2026-09-28 · current release · diff ↗ ·
added 5 exports
fastDist, fastDistAA, seqMismatchCount, seqMismatchMatrix, seqMismatchPositions - 1.4.32026-04-29 · diff ↗
- RR 4.6.0 released · 2026-04-24
- 1.4.22025-12-16 · diff ↗
- 1.4.12025-10-02 · diff ↗
- 1.4.02025-09-25 · diff ↗
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.3.02023-09-30 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 1.2.12022-09-21 · diff ↗
- RR 4.2.0 released · 2022-04-22
- 1.2.0
- RR 4.1.0 released · 2021-05-18
- 1.1.02021-02-07 · diff ↗ ·
added 6 exports
DNA_IUPAC, getChain, getLocus, getPositionQuality, maskPositionsByQuality, readFastqDb - 1.0.22020-07-19 · diff ↗
Show 19 earlier eventsHide 19 earlier events
- 1.0.12020-05-11 · diff ↗
- 1.0.02020-05-08 · diff ↗
- RR 4.0.0 released · 2020-04-24
- 0.3.02019-07-18 · diff ↗ ·
added 5 exports
alphaDiversity, combineIgphyml, graphToPhylo, phyloToGraph, readIgphyml - RR 3.6.0 released · 2019-04-26
- 0.2.112018-09-14 · diff ↗ ·
added 6 exports
baseTheme, checkColumns, cpuCount, groupGenes, nonsquareDist, progressBar - RR 3.5.0 released · 2018-04-23
- 0.2.102018-03-30 · diff ↗
- 0.2.92018-03-22 · diff ↗ ·
removed 1 export
plotAbundanceadded 3 exports
padSeqEnds, plotAbundanceCurve, plotDiversityTest - 0.2.82017-09-21 · diff ↗
- 0.2.72017-06-15 · diff ↗
- RR 3.4.0 released · 2017-04-21
- 0.2.62017-03-23 · diff ↗
- 0.2.52016-08-06 · diff ↗
- 0.2.42016-07-29 · diff ↗ ·
removed 4 exports
getSeqDistance, getSeqMatrix, multiggplot, testSeqEqualadded 16 exports
getMRCA, getPathLengths, gridPlot, pairwiseDist, pairwiseEqual, permuteLabels, plotEdgeTest, plotMRCATest, plotSubtrees, seqDist, seqEqual, sortGenes, summarizeSubtrees, tableEdges, testEdges, testMRCA - RR 3.3.0 released · 2016-05-03
- 0.2.32016-02-22 · diff ↗
- 0.2.22016-01-29
- RR 3.2.0 released · 2015-04-16
Package metadata
- First published
- 2016-01-29
- Total releases
- 23 / 10 yrs
- License
- AGPL-3 OSI · relicensed from CC BY-SA 4.0 in 1.0.0
- Minimum R
- ≥ 4.0
- Bundled data
- 298 KB / 5 files
- Download size
- 1.5 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("alakazam")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1093/bioinformatics/btv359, 10.1126/scitranslmed.3008879.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.