tigger
1.2.0Infers Novel Immunoglobulin Alleles from Sequencing Data
Overview
Infers the V genotype of an individual from immunoglobulin (Ig) repertoire sequencing data (AIRR-Seq, Rep-Seq). Includes detection of any novel alleles. This information is then used to correct existing V allele calls from among the sample sequences. Citations: Gadala-Maria, et al (2015) doi:10.1073/pnas.1417683112, Gadala-Maria, et al (2019) doi:10.3389/fimmu.2019.00129.
General:
- Updated dependencies to alakazam >= 1.5.0.
New Features:
- Added the function
plotGenotypeConfidence, which draws a genotype next to a color panel showing a per-gene confidence value, such as thek_diffreturned byinferGenotypeBayesian. - Added the
genotyped_allelesargument toinferGenotypeBayesian. WhenTRUE, agenotyped_allelescolumn is added with the most likely alleles based on the highest Bayesian zygosity likelihood. - Added the
allele_colargument toplotGenotypeto choose the column of alleles to plot (e.g.,allele_col="genotyped_alleles"). - Added the
include_unseenandstrip_darguments togenotypeFasta. Withinclude_unseen=TRUE, germline alleles of genes absent from the genotype are also returned.genotypeFastanow uses thegenotyped_allelescolumn, when present, instead ofalleles.
Show all changes in 1.2.0Hide the rest of the changes in 1.2.0
- Added the
trim_seq,overwrite,ignored_regex,treat_multigene_as_uncalled,top_k,top_by,strip_dandreassign_uncalledarguments toreassignAlleles. reassignAllelesnow supports D and J calls. The segment is determined from the prefix of thev_callargument, and the result is written to thev_call_genotyped,d_call_genotypedorj_call_genotypedcolumn accordingly. Thev_callcolumn name must now begin withv,dorj.
Backwards Incompatible Changes:
- When
gene_cutoffis a fraction,inferGenotypenow computes the cutoff from the number of sequences of the gene's locus instead of the whole repertoire.inferGenotypeandinferGenotypeBayesianwarn when calls from more than one locus are detected.
Bug Fixes:
- Fixed
reassignAllelesnot realigning sequences when only one sequence had a gene absent from the genotype.
Performance:
reassignAllelesnow usesalakazam::seqMismatchMatrixandalakazam::seqMismatchCountto compute Hamming distances, and parses allele calls only once per unique call.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-04
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- OK13 OK2026-05-10
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- ERROR12 OK, 1 ERROR2026-05-03
- OK12 OK2026-04-25
- ERROR13 OK, 1 ERROR2026-03-30
- OK14 OK2026-03-10
Documentation
- Help pages
- 29 (1 internal)includes a package overview page
- Examples that run
- 81%17 run in a plain check · 2 only when donttest examples are enabled (R CMD check --as-cran) · 2 hold no code
- Exported functions with examples
- 100%
- Documented parameters
- 99%
- Return-value docs
- 95%
- Help pages citing references
- 31%
Downloads
Repository
- PRs merged (all time)
- 100%
- Median days to close, 50 most recently updated closed issues
- 10
- Median days to close, 50 most recently updated closed PRs
- 1
Stars over time
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Issues over time
PRs over time
Commits over time
4 development-tooling and community-health practices detected across 2 families in the upstream repository
Checks run against github.com/immcantation/tigger on 2026-10-11.
The R CMD check workflow runs on Linux
Dependencies
Installing tigger adds 59 packages (33 with compiled code, 55 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, igraph 4.8 MB. 3 more not on CRAN are not measured.
Code & Tests
Datasets
People & History
Previously maintained by Jason Vander Heiden (0.2.10 to 1.0.0) and Daniel Gadala-Maria (0.2.5 to 0.2.9.999).
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- 1.2.0Latest
- RR 4.6.0 released · 2026-04-24
- 1.1.32026-04-17 · diff ↗
- 1.1.22026-01-10 · diff ↗
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.1.02023-10-10 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 1.0.12022-09-20 · diff ↗
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 1.0.0
- RR 4.0.0 released · 2020-04-24
- 0.4.02019-07-19 · diff ↗
- RR 3.6.0 released · 2019-04-26
- 0.3.12018-10-19 · diff ↗
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Package metadata
- First published
- 2016-06-08
- Total releases
- 15 / 10 yrs
- License
- AGPL-3 OSI · relicensed from CC BY-SA 4.0 in 1.0.0
- Minimum R
- ≥ 4.0
- Bundled data
- 2.5 MB / 6 files
- Download size
- 2.7 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("tigger")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1073/pnas.1417683112, 10.3389/fimmu.2019.00129.
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