R Observatory: Metrics for mmrm version 0.3.19

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

mmrm

0.3.19

Mixed Models for Repeated Measures

5packages dependsuggested by 8

86.4Kdownloads / year

97.8%test coverage

13/13flavors OK

Overview

About

Maintained by Daniel Sabanes BoveCRAN page ↗GitHub ↗Website ↗Issues ↗Declared funders: AstraZeneca plc, Boehringer Ingelheim Ltd. and 4 more

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) doi:10.1177/009286150804200402 for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.

Changes in 0.3.19

Bug Fixes

emmeans() now uses the fitted fixed-effect terms to construct its coefficient basis. This fixes incorrect marginal means and uncertainty estimates for models where the visit variable appears only in interactions, such as treatment-by-visit models without a visit main effect.

Miscellaneous

Satterthwaite, empirical and linear Kenward-Roger covariance preparation now skip unused second derivatives. Linear Kenward-Roger also omits the R component and its allocation.
Linear Kenward-Roger (vcov = "Kenward-Roger-Linear") now calculates the adjusted coefficient covariance from contracted sums instead of looping over all pairs of covariance parameters. This is substantially faster for models with many covariance parameters, e.g. unstructured covariance with many visits, and gives the same results up to floating-point error. Consequently, the kr_comp element of such fits now contains P and the contracted matrix S_Q, while Q and R are NULL. Full Kenward-Roger fits are unchanged.
Kenward-Roger degrees of freedom now use contrast-space matrix contractions and a direct scalar shortcut, preserving the existing formulas while reducing contrast inference time.
For one-dimensional Kenward-Roger contrasts whose variance does not depend on the covariance parameters (zero moment), the degrees of freedom are now Inf with F scaling 1, which is the limit of the formulas, instead of NaN.

From NEWS.md in the release

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("mmrm", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("openpharma/mmrm")

Development version from openpharma/mmrm. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-mmrm

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-mmrm

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-mmrm

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 21.1 min · r-oldrel-windows-x86_64

Status changes

OK13 OK2026-08-05
NOTE12 OK, 1 NOTE2026-08-01
OK13 OK2026-07-18
WARNING12 OK, 1 WARNING2026-07-16
OK13 OK2026-06-23

Show 8 earlier changesHide 8 earlier changes

ERROR12 OK, 1 ERROR2026-06-20
OK13 OK2026-06-12
ERROR12 OK, 1 ERROR2026-06-05
OK13 OK2026-05-07
ERROR10 OK, 3 NOTE, 1 ERROR2026-04-23
NOTE11 OK, 3 NOTE2026-04-22
ERROR10 OK, 3 NOTE, 1 ERROR2026-04-18
NOTE11 OK, 3 NOTE2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 0.3.19

README· In the repository, left out of the releaseVignettesYes · 14 · dynamicNEWSYes · 100% structured · mentions 0.3.19Citation fileNoWebsiteYes · pkgdown

Help pages: 130 (108 internal)includes a package overview page
Examples that run: 100%15 run in a plain check
Exported functions with examples: 73%
Documented parameters: 89%
Return-value docs: 93%
Help pages citing references: 1% with a bibliography file

Vignettes (14)

Show 4 moreHide 4 vignettes

How these are measured

Downloads

86.4K

CRAN downloads in the past year

Rank #1,416 · ~237/day · ~7.2K/mo

Releases R versions

Daily download trend is not available in this view yet.

7.4K30 days

18.8K90 days

86.4K1 year

Compare downloads with other packages →

Also on1K r2u7 autocran1.9K conda_forge78 c2d4u

How downloads are counted

Repository

openpharma/mmrm ↗Organization: openpharma

161Stars

28Forks

21Open issues

0Open PRs

14Releases

437Commits

30Commit identities

437 commits · Last activity 2026-10-14 · 0% stars, 30d · Discussions: 12 posts

Responsiveness

How these are sampled

PRs merged (all time): 94%
Median days to close, 50 most recently updated closed issues: 19
Median days to close, 50 most recently updated closed PRs: 1

Stars over time

2025-09-23 · 1482026-09-12 · 161

How these are measured

PracticesBeta

15 development-tooling and community-health practices detected across 7 families in the upstream repository

Checks run against github.com/openpharma/mmrm on 2026-10-11.

Continuous integration (1)

GitHub Actions

Governance and community (5)

Contributing guideIssue templatesPR templateFundingCODEOWNERS

Funding links: GitHub Sponsors

Docs source (3)

README.Rmdpkgdown

GitHub Pages site last deployed 2026-10-07

pkgdown site last built 2026-10-07

Coverage (1)

Coverage reporting

Show all practicesHide 3 practices

Reproducibility and dev environment (1)

data-raw/

Automation and maintenance (1)

pre-commit

Lint, format, editor (3)

lintrAirRStudio project

How this is detected·Detection ruleset v3 (2026-09-26)

AI coding toolsBeta

This repository has an AI review tool set up.

Review tools

Copilot code review
Commits: some accepting its review suggestions, count not recorded

How this is detected·Detection ruleset v4 (updated 2026-09-27)

Dependencies

Declared dependencies

39 external dependencies (excludes base and recommended)

Installing mmrm adds 39 packages (21 with compiled code, 26 MB of source tarballs). Heaviest: stringi 11 MB, Rcpp 1.8 MB, RcppEigen 1.7 MB.

Depends (1)

R >= 4.1

Imports (15)

checkmate generics lifecycleMASSMatrixmethodsnlmeparallelRcpp Rdpackstatsstringr tibble TMButils

LinkingTo (4)

Rcpp RcppEigen testthat TMB

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

5direct

3indirect

Imports 5

Suggested by 8

Show all 13 packagesHide all 13 packages

Depends, Imports or LinkingTo, most downloaded first

tern.mmrm rbmi junco multipleOutcomes splinetrials

Suggests, most downloaded first

insight parameters marginaleffects clubSandwich broom.helpers DoseFinding brms.mmrm crane

How these are counted

Code & Tests

Datasets

People & History

People (23)

Daniel Sabanes Bove

Author, Maintainer since 0.1.3 (2022)

Julia Dedic

Author

Dan James

Author · added in 0.3.6

Jeremiah Jones

Author · added in 0.3.18

Doug Kelkhoff

Author

Nikolas Ivan Krieger

Author · added in 0.3.15

Kevin Kunzmann

Author

Brian Matthew Lang

Author

Daniel Leibovitz

Author · added in 0.3.6

Liming Li

Author

Arryn Panagos

Author · added in 0.3.18

Jonathan Sidi

Author · added in 0.3.6

Daniel D. Sjoberg

Author · added in 0.3.6

Christian Stock

Author · added in 0.3.6

Ya Wang

Author

Craig Gower-Page

Contributor

Lukas A. Widmer

Contributor · added in 0.3.14

AstraZeneca plc

Copyright holder, Funder · added in 0.3.6

Boehringer Ingelheim Ltd.

Copyright holder, Funder

F. Hoffmann-La Roche AG

Copyright holder, Funder

Gilead Sciences, Inc.

Copyright holder, Funder

Merck Sharp & Dohme, Inc.

Copyright holder, Funder

inferential.biostatistics GmbH

Copyright holder, Funder · added in 0.3.13

Releases (17)

Pick two releases to compare their code metrics.

0.3.19Latest
record
2026-10-06 · current release · diff ↗ ·
listed once in CRAN's queue
Seen in one reading of CRAN's incoming queue, at 2026-10-06 15:36 UTC, so it stayed less than the time between readings.
0.3.18
record
2026-06-19 · diff ↗
R
R 4.6.0 released · 2026-04-24
0.3.17
record
2026-01-08 · diff ↗
0.3.16
record
2025-12-09 · diff ↗
0.3.15
record
2025-06-10 · diff ↗
R
R 4.5.0 released · 2025-04-11
0.3.14
record
2024-09-28 · diff ↗
0.3.13
record
2024-09-23 · diff ↗
0.3.12
record
2024-06-26 · diff ↗
R
R 4.4.0 released · 2024-04-24
0.3.11
record
2024-03-05 · diff ↗
0.3.10
record
2024-01-26 · diff ↗
0.3.9
record
2024-01-25 · diff ↗
0.3.8
record
2024-01-24 · diff ↗ ·
added 2 exports
emp_start, std_start
0.3.7
record
2023-12-09 · diff ↗

Show 6 earlier eventsHide 6 earlier events

0.3.6
record
2023-11-17 · diff ↗ ·
removed 1 export
free_cores

added 6 exports
as.cov_struct, augment, cov_struct, cov_types, glance, tidy
R
R 4.3.0 released · 2023-04-21
0.2.2
record
2022-12-20 · diff ↗
0.1.5
record
2022-10-18 · diff ↗
0.1.3
record
2022-10-18
R
R 4.2.0 released · 2022-04-22

Across CRAN, the median accepted release of the past year spent 19 hours in the queue, 90% under 11 days.How queue time is measured

Package metadata

First published: 2022-10-18
Total releases: 17 / 4 yrs
License: Apache License 2.0 OSI
Minimum R: ≥ 4.1
Bundled data: 126 KB / 3 files
Download size: 1.2 MB

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Mixed, Multilevel, and Hierarchical Models in R

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("mmrm")

Format

Sabanes Bove, D., AstraZeneca plc, Boehringer Ingelheim Ltd., F. Hoffmann-La Roche AG, Gilead Sciences, Inc., Merck Sharp & Dohme, Inc., inferential.biostatistics GmbH, Dedic, J., Gower-Page, C., James, D., Jones, J., Kelkhoff, D., Krieger, N. I., Kunzmann, K., Lang, B. M., Leibovitz, D., Li, L., Panagos, A., Sidi, J., Sjoberg, D. D., Stock, C., Wang, Y., & Widmer, L. A. (2026). mmrm: Mixed Models for Repeated Measures (Version 0.3.19) [Computer software]. https://doi.org/10.32614/CRAN.package.mmrm

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for mmrm version 0.3.19 [Data set]. HJJB, LLC. Data release v2026-10-17. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-17, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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