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splinetrials

0.1.1Package record

Facilitate Clinical Trials Analysis Using Natural Cubic Splines

0packages depend
1.9Kdownloads / year
88.9%test coverage
13/13flavors OK

Overview

About

Create mixed models with repeated measures using natural cubic splines applied to an observed continuous time variable, as described by Donohue et al. (2023) doi:10.1002/pst.2285. Iterate through multiple covariance structure types until one converges. Categorize observed time according to scheduled visits. Perform subgroup analyses.

Changes in 0.1.1
  • Catch novel non-convergence error. Not catching these had made it so that model fitting would just quit because the program thought it was a different kind of error the user had to figure out (e.g., syntax).
  • Removed errant time_scheduled_continuous argument in ncs_mmrm_fit().
  • Improved pkgdown site, categorizing functions in the function reference.
  • Improved README, basing it on survival::pbcseq instead of randomly generated data.

From NEWS.md in the release

Install

Health

CRAN checks
13OK
Slowest check: 2.2 min · r-oldrel-windows-x86_64
Status changes
  • OK13 OK2026-08-04
  • NOTE12 OK, 1 NOTE2026-08-01
  • OK13 OK2026-06-09
  • ERROR12 OK, 1 ERROR2026-06-08
  • OK14 OK2026-03-10
Advisories

none known

Documentation

In release 0.1.1
READMEYes · 1,333 wordsVignettesNoNEWSYes · 100% structured · mentions 0.1.1Citation fileNoWebsiteYes · pkgdown
Help pages
15
Examples that run
100%13 run in a plain check (3 of them under a condition)
Exported functions with examples
100%
Documented parameters
66%
Return-value docs
100%
Help pages citing references
0%

Downloads

1.9K
CRAN downloads in the past year
Rank #23,534 · ~5/day · ~157/mo
Daily download trend is not available in this view yet.
19830 days
54390 days
1.9K1 year
Compare downloads with other packages →
Also on60 r2u8 autocran

Repository

3Stars
0Forks
1Open issues
0Open PRs
1Releases
26Commits
2Commit identities
License file reads as Apache-2.0 · 26 commits · Last activity 2026-08-10 · Default branch at 0.1.1.9001, ahead of CRAN 0.1.1 (checked 2026-10-18)
Responsiveness
How these are sampled
PRs merged (all time)
100%
Median days to close, 50 most recently updated closed issues
0
Median days to close, 50 most recently updated closed PRs
9

Commits over time

2026-07-19 · 232026-08-16 · 26
PracticesBeta

9 development-tooling and community-health practices detected across 5 families in the upstream repository

Checks run against github.com/nikkrieger/splinetrials on 2026-10-18.

Continuous integration (2)
GitHub ActionsR CMD check workflow

The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel

Docs source (4)
README.Rmdpkgdown

GitHub Pages site last deployed 2026-08-10 · The repository has a site deploy workflow

pkgdown site last built 2026-08-10

Coverage (1)
Coverage reporting (Codecov)
CRAN release process (1)
cran-comments.md
Show all practicesHide 1 practice
Lint, format, editor (1)
RStudio project
How this is detected·Detection ruleset v3 (2026-09-26)

Dependencies

Declared dependencies
8 external dependencies (excludes base and recommended)

Installing splinetrials adds 83 packages (43 with compiled code, 64 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, doBy 4.3 MB.

Depends (0)
none
Imports (7)
LinkingTo (0)
none
Suggests (3)
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (3)
Author, Maintainer since 0.1.0 (2025)
Copyright holder
Releases (2)

Pick two releases to compare their code metrics.

  • R
    R 4.6.0 released · 2026-04-24
  • 0.1.1Latest
    record
    2026-01-19 · current release · diff ↗
  • 0.1.0
    record
    2025-12-18
  • R
    R 4.5.0 released · 2025-04-11

Package metadata

First published
2025-12-18
Total releases
2 / 1 yrs
License
Apache License (>= 2)
Download size
241 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("splinetrials")
Krieger, N., Eli Lilly and Company, & Sabanes Bove, D. (2026). splinetrials: Facilitate Clinical Trials Analysis Using Natural Cubic Splines (Version 0.1.1) [Computer software]. https://doi.org/10.32614/CRAN.package.splinetrials

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for splinetrials version 0.1.1 [Data set]. HJJB, LLC. Data release v2026-10-21. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-21, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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