Omics Data Integration Project
Overview
Multivariate methods are well suited to large omics data sets where the number of variables (e.g. genes, proteins, metabolites) is much larger than the number of samples (patients, cells, mice). They have the appealing properties of reducing the dimension of the data by using instrumental variables (components), which are defined as combinations of all variables. Those components are then used to produce useful graphical outputs that enable better understanding of the relationships and correlation structures between the different data sets that are integrated. mixOmics offers a wide range of multivariate methods for the exploration and integration of biological datasets with a particular focus on variable selection. The package proposes several sparse multivariate models we have developed to identify the key variables that are highly correlated, and/or explain the biological outcome of interest. The data that can be analysed with mixOmics may come from high throughput sequencing technologies, such as omics data (transcriptomics, metabolomics, proteomics, metagenomics etc) but also beyond the realm of omics (e.g. spectral imaging). The methods implemented in mixOmics can also handle missing values without having to delete entire rows with missing data. A non exhaustive list of methods include variants of generalised Canonical Correlation Analysis, sparse Partial Least Squares and sparse Discriminant Analysis. Recently we implemented integrative methods to combine multiple data sets: N-integration with variants of Generalised Canonical Correlation Analysis and P-integration with variants of multi-group Partial Least Squares.
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Documentation
- Help pages
- 82
- Examples that run
- 77%49 run in a plain check · 9 never run · 6 hold no code
- Exported functions with examples
- 97%
- Documented parameters
- 92%
- Return-value docs
- 85%
- Help pages citing references
- 74%
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Dependencies
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Code & Tests
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Maintainer since 2.6 (2010)
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- RR 3.6.0 released · 2019-04-26
- 6.3.2
- 6.3.2archived2018-06-01 · diff ↗This package is now available from Bioconductor only, see <https://www.bioconductor.org/packages/release/bioc/html/mixOmics.html>
- RR 3.5.0 released · 2018-04-23
- 6.3.1
- 6.3.0
- 6.2.02017-08-17 · diff ↗
- 6.1.3
- RR 3.4.0 released · 2017-04-21
- 6.1.2
- 6.1.1
- 6.1.0
- 6.0.02016-06-14 · diff ↗ ·
removed 20 exports
bin.color, cov2, deflation, defl.select, ica.par, ica.def, initsvd, loo, l2.norm, Mfold, miscrossprod, pcasvd, scale2, s.match, soft_thresholding_L1, soft.threshold, sparsity, tau.estimate, tune.splsdalevel1, tune.splsdalevel2added 23 exports
block.pls, block.plsda, block.spls, block.splsda, cimDiablo, circosPlot, explained_variance, logratio.transfo, mint.block.pls, mint.block.plsda, mint.block.spls, mint.block.splsda, mint.pls, mint.plsda, mint.spls, mint.splsda, mixOmics, plotDiablo, plotLoadings, study_split, tune, tune.mint.splsda, tune.splsda - RR 3.3.0 released · 2016-05-03
- 5.2.02015-11-19 · diff ↗ ·
removed 3 exports
pheatmap.multilevel, plot3dIndiv, plot3dVaradded 1 export
plotArrow - 5.1.22015-08-29 · diff ↗
Show 27 earlier eventsHide 27 earlier events
- 5.1.12015-07-30 · diff ↗ ·
removed 2 exports
tau.estim, validadded 13 exports
cov2, deflation, defl.select, initsvd, l2.norm, miscrossprod, plotContrib, scale2, soft_thresholding_L1, soft.threshold, sparsity, tau.estimate, wrapper.sgccda - 5.0-42015-04-28 · diff ↗ ·
removed 7 exports
check.one.level, jet.colors, multilevel.splsda, multilevel.spls, select.var, Split.variation.one.level, Split.variation.two.leveladded 7 exports
color.jet, color.GreenRed, color.spectral, color.mixo, selectVar, tau.estim, withinVariation - RR 3.2.0 released · 2015-04-16
- RR 3.1.0 released · 2014-04-10
- RR 3.0.0 released · 2013-04-03
- 5.0-3
- 5.0-22012-12-11 · diff ↗ ·
removed 3 exports
spls.model, splsda.model, validadded 2 exports
check.one.level, perf - 5.0-12012-12-11 · diff ↗ ·
removed 5 exports
estim.regul, image.estim.regul, pcatune, q2.spls, q2.plsadded 5 exports
image.tune.rcc, tune.pca, tune.rcc, wrapper.rgcca, wrapper.sgcca - 4.1-52012-12-11 · diff ↗
- 4.1-42012-12-11 · diff ↗
- 4.1-3
- RR 2.15.0 released · 2012-03-30
- RR 2.14.0 released · 2011-10-31
- 4.0-22011-04-28 · diff ↗
- 4.0-12011-04-28 · diff ↗ ·
added 10 exports
multilevel, multilevel.splsda, multilevel.spls, pheatmap.multilevel, Split.variation.one.level, Split.variation.two.level, tune.multilevel, tune.splsdalevel1, tune.splsdalevel2, tune.splslevel - 3.0
- 2.9-6
- RR 2.13.0 released · 2011-04-13
- RR 2.12.0 released · 2010-10-15
- RR 2.11.0 released · 2010-04-22
- 2.9-4
- 2.9-22010-02-15 · diff ↗
- 2.9-12010-02-15 · diff ↗
- 2.8-1
- 2.7-1
- 2.62010-02-15
- RR 2.10.0 released · 2009-10-26
Package metadata
- First published
- 2010-02-15
- Total releases
- 29 / 16 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 2.10
- Bundled data
- 2.9 MB / 14 files
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