ASSIGN

Description

ASSIGN is a computational tool to evaluate the pathway deregulation/activation status in individual patient samples. ASSIGN employs a flexible Bayesian factor analysis approach that adapts predetermined pathway signatures derived either from knowledge-based literature or from perturbation experiments to the cell-/tissue-specific pathway signatures. The deregulation/activation level of each context-specific pathway is quantified to a score, which represents the extent to which a patient sample encompasses the pathway deregulation/activation signature.

Code

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Topics

Depended on by (1)

People

• David Jenkins author maintainer
• Andrea H. Bild author
• W. Evan Johnson author
• Mumtehena Rahman author
• Ying Shen author