R Observatory: Metrics for PKNCA version 0.12.1

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

PKNCA

0.12.1Package record

Perform Pharmacokinetic Non-Compartmental Analysis

4packages dependsuggested by 1

33.1Kdownloads / year

99.0%test coverage

13/13flavors OK

Overview

About

Maintained by Bill DenneyCRAN page ↗GitHub ↗Website ↗Issues ↗

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

Changes in 0.12.1

Minor changes (unlikely to affect PKNCA use)

Units for fraction excretion parameter (fe) are now accurately captured as amount/dose units rather than "fraction" (#426)
get_halflife_points will ignore points after lambda.z.time.last, instead of tlast (#448)
lambda.z calculations will now only consider time points that occur after the end of the latest dose administration (#139)
aucint.inf.pred is NA when half-life is not estimable (#450)

New features

PKNCA now has a debugging mode to support troubleshooting; it is not intended for production use. Debugging mode can be enabled using PKNCA.options(debug = TRUE).

From NEWS.md in the release

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("PKNCA", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("humanpred/pknca")

Development version from humanpred/pknca. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-pknca

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-PKNCA

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-PKNCA

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 7.4 min · r-oldrel-windows-x86_64

Status changes

OK13 OK2026-08-05
NOTE12 OK, 1 NOTE2026-08-01
OK13 OK2026-07-03
ERROR12 OK, 1 ERROR2026-06-27
OK14 OK2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 0.12.1

READMEYes · 402 wordsVignettesYes · 18 · evaluation depends on the environmentNEWSYes · 100% structured · mentions 0.12.1Citation fileYes · cites a publicationWebsiteYes · pkgdown

Help pages: 146 (2 internal)includes a package overview page
Examples that run: 82%14 run in a plain check · 3 never run
Exported functions with examples: 16%
Documented parameters: 97%
Return-value docs: 91%
Help pages citing references: 5%

Vignettes (18)

Show 8 moreHide 8 vignettes

How these are measured

Downloads

33.1K

CRAN downloads in the past year

Rank #2,349 · ~91/day · ~2.8K/mo

Releases R versions

Daily download trend is not available in this view yet.

2.7K30 days

7.2K90 days

33.1K1 year

Compare downloads with other packages →

Also on529 r2u4 autocran152 c2d4u

How downloads are counted

Repository

humanpred/pknca ↗Organization: humanpred

89Stars

32Forks

3Open issues

5Open PRs

10Releases

1,895Commits

14Commit identities

noncompartmental-analysiscranrncapharmacokinetics

License file reads as AGPL-3.0 · 1,895 commits · Last activity 2026-10-22 · +3.5% stars, 30d · Default branch at 0.12.1.9002, ahead of CRAN 0.12.1 (checked 2026-10-22) · Discussions: 63 posts

Responsiveness

How these are sampled

PRs merged (all time): 93%
Median days to close, 50 most recently updated closed issues: 588
Median days to close, 50 most recently updated closed PRs: 0

Stars over time

2025-05-27 · 772026-10-23 · 89

How these are measured

PracticesBeta

11 development-tooling and community-health practices detected across 6 families in the upstream repository

Checks run against github.com/humanpred/pknca on 2026-10-22.

Continuous integration (2)

GitHub ActionsR CMD check workflow

The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel

Governance and community (3)

Code of conductContributing guideIssue templates

Docs source (3)

pkgdown

GitHub Pages site last deployed 2026-10-22 · The repository has a site deploy workflow

pkgdown site last built 2026-10-22

Coverage (1)

Coverage reporting (Codecov)

Show all practicesHide 2 practices

Reproducibility and dev environment (1)

data-raw/

Git structural (1)

.gitattributes

How this is detected·Detection ruleset v4 (2026-10-20)

AI coding toolsBeta

This repository shows signs of AI coding tools.

Claude Codefirst seen 2026-03-03
Seen in the repository: CLAUDE.md
Named in .Rbuildignore: .claude, CLAUDE.md
Named in .gitignore: .claude
Pull request it wrote: opened by a project member
Commits: 8 by its own account · at least 420 crediting it in the message

From outside contributors

Claude Code
Pull requests: 1 from outside contributors, first on 2026-10-07, 1 from forks

Models named in its commits

Claude Sonnet 4.631 commits · Mar to May 2026
Claude Opus 4.827 commits · Jun to Jul 2026
Claude Fable 521 commits · Jun to Aug 2026
Claude Opus 4.611 commits · Mar 2026
Claude Opus 59 commits · Aug 2026

1 more model not listed. Some of these counts are a minimum, because the search stopped before the oldest commits.

Counts are commits, not lines of code. Commits by a tool's accounts count once across all of its accounts. Commits crediting it are the largest count among its credit lines, a minimum.How this is detected·Detection ruleset v4 (updated 2026-09-27)

Dependencies

Declared dependencies

20 external dependencies (excludes base and recommended)

Installing PKNCA adds 23 packages (15 with compiled code, 18 MB of source tarballs). Heaviest: stringi 11 MB, vctrs 1.0 MB, dplyr 902 KB.

Depends (0)

none

Imports (11)

checkmate dplyr digestnlmepurrr rlangstatstidyr tibbleutilslifecycle

LinkingTo (0)

none

Suggests (12)

covr cowplot ggplot2 knitr labeling pander pmxTools rmarkdown spelling testthat units withr

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

4direct

0indirect

Imports 4

Suggested by 1

Depends, Imports or LinkingTo, most downloaded first

pmxTools aNCA ruminate ubiquity

Suggests, most downloaded first

babelmixr2

How these are counted

Code & Tests

People & History

People (4)

Bill Denney

Author, Maintainer since 0.6 (2015)

Clare Buckeridge

Author

Gerardo Jose Rodriguez

Author · added in 0.12.1

Sridhar Duvvuri

Contributor · added in 0.7.1

Releases (17)

Pick two releases to compare their code metrics.

R
R 4.6.0 released · 2026-04-24
0.12.1Latest
record
2025-08-19 · current release · diff ↗ ·
added 2 exports
exclude_nca_by_param, exclude_nca_min.hl.adj.r.squared
0.12.0
record
2025-05-08 · diff ↗ ·
added 7 exports
assert_intervals, exclude_nca_count_conc_measured, exclude_nca_tmax_0, exclude_nca_tmax_early, get_halflife_points, pk.calc.count_conc_measured, set_intervals
R
R 4.5.0 released · 2025-04-11
0.11.0
record
2024-06-19 · diff ↗ ·
removed 1 export
pk.calc.vd

added 6 exports
as_PKNCAconc, as_PKNCAdata, as_PKNCAdose, as_PKNCAresults, pk.calc.count_conc, pk.calc.totdose
R
R 4.4.0 released · 2024-04-24
0.10.2
record
2023-04-29 · diff ↗
R
R 4.3.0 released · 2023-04-21
0.10.1
record
2023-01-11 · diff ↗ ·
removed 2 exports
findOperator, parseFormula

added 2 exports
pk.calc.aucabove, pk.calc.cstart
0.10.0
record
2022-10-16 · diff ↗ ·
added 22 exports
PKNCA_impute_method_start_cmin, PKNCA_impute_method_start_conc0, PKNCA_impute_method_start_predose, as_sparse_pk, cov_holder, filter, full_join, group_by, inner_join, is_sparse_pk, left_join, mutate, pk.calc.auciv, pk.calc.auciv_pbext, pk.calc.sparse_auc, pk.calc.sparse_auclast, pknca_units_table, right_join, sparse_auc_weight_linear, sparse_mean, ungroup, var_sparse_auc
R
R 4.2.0 released · 2022-04-22
0.9.5
record
2021-10-29 · diff ↗ ·
added 1 export
pk.calc.time_above
R
R 4.1.0 released · 2021-05-18
0.9.4
record
2020-06-01 · diff ↗
R
R 4.0.0 released · 2020-04-24
0.9.3
record
2020-04-12 · diff ↗

Show 15 earlier eventsHide 15 earlier events

0.9.2
record
2020-02-28 · diff ↗ ·
added 2 exports
PKNCA.options.describe, time_calc
0.9.1
record
2019-07-29 · diff ↗
R
R 3.6.0 released · 2019-04-26
0.8.5
record
2018-06-13 · diff ↗
R
R 3.5.0 released · 2018-04-23
unarchivedReturned to CRAN
2018-01-03
0.8.4
record
2018-01-03 · diff ↗ ·
removed 17 exports
pk.calc.aucpext.obs, pk.calc.aucpext.pred, pk.calc.cl.all, pk.calc.cl.last, pk.calc.cl.obs, pk.calc.cl.pred, pk.calc.kel.obs, pk.calc.kel.pred, pk.calc.mrt.last, pk.calc.mrt.obs, pk.calc.mrt.pred, pk.calc.vd.obs, pk.calc.vd.pred, pk.calc.vss.obs, pk.calc.vss.pred, pk.calc.vz.obs, pk.calc.vz.pred

added 17 exports
add.interval.col, exclude_nca_max.aucinf.pext, exclude_nca_min.hl.r.squared, exclude_nca_span.ratio, getGroups, pk.calc.ae, pk.calc.aucint, pk.calc.aucint.all, pk.calc.aucint.inf.obs, pk.calc.aucint.inf.pred, pk.calc.aucint.last, pk.calc.ceoi, pk.calc.clr, pk.calc.dn, pk.calc.fe, pk.calc.mrt.iv, pk.calc.mrt.md
orphanedOrphaned by its maintainer
2017-12-16
there was no response to requests for needed corrections
0.8.1
record
2017-12-16 · diff ↗ ·
removed 2 exports
count.non.missing, sapplyBy

added 31 exports
addProvenance, checkProvenance, exclude, get.parameter.deps, interp.extrap.conc.dose, pk.calc.auc.inf.obs, pk.calc.auc.inf.pred, pk.calc.aucpext.obs, pk.calc.aucpext.pred, pk.calc.aumc.inf.obs, pk.calc.aumc.inf.pred, pk.calc.cl.all, pk.calc.cl.last, pk.calc.cl.obs, pk.calc.cl.pred, pk.calc.cmin, pk.calc.deg.fluc, pk.calc.kel.obs, pk.calc.kel.pred, pk.calc.mrt.obs, pk.calc.mrt.pred, pk.calc.swing, pk.calc.tfirst, pk.calc.vd.obs, pk.calc.vd.pred, pk.calc.vss.obs, pk.calc.vss.pred, pk.calc.vz.obs, pk.calc.vz.pred, setDuration and 1 more
R
R 3.4.0 released · 2017-04-21
0.7.1
record
2016-08-15 · diff ↗ ·
added 11 exports
business.cv, business.geocv, business.geomean, business.max, business.median, business.min, business.range, business.sd, geocv, geosd, pk.calc.mrt.last
R
R 3.3.0 released · 2016-05-03
0.7
record
2016-04-01 · diff ↗ ·
added 2 exports
pk.calc.c0, pk.calc.vd
0.6
record
2015-11-22
R
R 3.2.0 released · 2015-04-16

Package metadata

First published: 2015-11-22
Total releases: 17 / 11 yrs
License: AGPL-3 OSI
Download size: 1.0 MB

Appears in task views

Mixed, Multilevel, and Hierarchical Models in R Analysis of Pharmacokinetic Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("PKNCA")

The package provides a citation file that builds its entry when R runs it. Run citation() to see it.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for PKNCA version 0.12.1 [Data set]. HJJB, LLC. Data release v2026-10-24. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-24, which the citation names so these numbers can be found later. More on citing and the projects behind them.

Report a problem with this page →