GRAB
Genome-Wide Robust Analysis for Biobank Data (GRAB)
Description
Provides a comprehensive suite of genome-wide association study (GWAS) methods specifically designed for biobank-scale data, including but not limited to, robust approaches for time-to-event traits (Li et al., 2025 <doi:10.1038/s43588-025-00864-z>) and ordinal categorical traits (Bi et al., 2021 <doi:10.1016/j.ajhg.2021.03.019>). The package also offers general frameworks for GWAS of any trait type (Bi et al., 2020 <doi:10.1016/j.ajhg.2020.06.003>), while accounting for sample relatedness (Xu et al., 2025 <doi:10.1038/s41467-025-56669-1>) or population structure (Ma et al., 2025 <doi:10.1186/s13059-025-03827-9>). By accurately approximating score statistic distributions using saddlepoint approximation (SPA), these methods can effectively control type I error rates for rare variants and in the presence of unbalanced phenotype distributions. Additionally, the package includes functions for simulating genotype and phenotype data to support research and method development.
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check History
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026
ERROR 12 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 8, 2026
examples
Running examples in ‘GRAB-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: GRAB.ReadGeno
> ### Title: Read genotype data from multiple file formats
> ### Aliases: GRAB.ReadGeno
>
...[truncated]...
026-06-07 12:58:46 Reading bgi file: simuBGEN.bgen.bgi
Error in check_dbplyr() :
The package "dbplyr" is required to communicate with database backends.
Calls: GRAB.ReadGeno ... tbl.DBIConnection -> check_dbplyr -> check_installed
Execution halted
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE May 2, 2026
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Apr 22, 2026
installed package size
installed size is 17.4Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 14.6Mb
installed package size
installed size is 18.1Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 15.2Mb
ERROR 11 OK · 2 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Apr 18, 2026
whether package can be installed
Installation failed. See 'd:/Rcompile/CRANpkg/local/4.6/GRAB.Rcheck/00install.out' for details.
installed package size
installed size is 17.4Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 14.6Mb
installed package size
installed size is 18.1Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 15.2Mb
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
installed package size
installed size is 17.4Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 14.6Mb
installed package size
installed size is 18.1Mb
sub-directories of 1Mb or more:
extdata 2.5Mb
libs 15.2Mb