Gene Set Analysis Exploiting Pathway Topology
Overview
Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques). The package is based on the method described in Massa M.S., Chiogna M., Romualdi C. (2010) doi:10.1186/1752-0509-4-121.
Install
Health
ERRORpackage dependenciesr-oldrel-macos-x86_64
Package required but not available: ‘qpgraph’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Gabriele Sales <gabriele.sales@unipd.it>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Sofia",
family = "Massa",
role = "aut"),
person(given = "Gabriele",
family = "Sales",
role = c("aut", "cre"),
email = "gabriele.sales@unipd.it"))
as necessary.- ERROR10 OK, 2 NOTE, 1 ERRORNow
- ERROR11 OK, 2 NOTE, 1 ERROR2026-03-10
Documentation
- Help pages
- 9
- Examples that run
- 100%5 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 80%
- Help pages citing references
- 56%
Downloads
Dependencies
Installing topologyGSA adds 19 packages (14 with compiled code, 25 MB of source tarballs). Heaviest: igraph 4.8 MB, fields 3.9 MB, spam 3.1 MB. 2 more not on CRAN are not measured.
Code & Tests
Datasets
People & History
Maintainer since 1.2.0 (2012), previously Sofia Massa (1.0 to 1.1.0)
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.5.0Latest
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- unarchivedReturned to CRAN2021-07-07
- 1.4.72021-07-07 · diff ↗
- archivedRemoved from CRAN2021-05-27check problems were not corrected in time
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- RR 3.4.0 released · 2017-04-21
- 1.4.62016-09-22 · diff ↗
- RR 3.3.0 released · 2016-05-03
Show 18 earlier eventsHide 18 earlier events
- 1.4.52015-07-09 · diff ↗ ·
removed 4 exports
print.clique.var.test, print.clique.mean.test, print.pathway.var.test, print.pathway.mean.test - RR 3.2.0 released · 2015-04-16
- 1.4.42014-08-02 · diff ↗ ·
added 4 exports
print.clique.var.test, print.clique.mean.test, print.pathway.var.test, print.pathway.mean.test - RR 3.1.0 released · 2014-04-10
- 1.4.32014-03-26 · diff ↗
- 1.4.22013-12-12 · diff ↗
- 1.4.12013-11-19 · diff ↗
- 1.4.02013-10-23 · diff ↗
- 1.2.12013-06-26 · diff ↗
- RR 3.0.0 released · 2013-04-03
- 1.2.02013-03-01 · diff ↗
- 1.1.02012-07-18 · diff ↗
- RR 2.15.0 released · 2012-03-30
- 1.0.32011-12-22 · diff ↗
- 1.0.22011-11-10 · diff ↗
- RR 2.14.0 released · 2011-10-31
- 1.02011-06-24
- RR 2.13.0 released · 2011-04-13
Package metadata
- First published
- 2011-06-24
- Total releases
- 15 / 15 yrs
- License
- GPL-3 OSI · relicensed from AGPL-3 in 1.4.4
- Bundled data
- 6.5 KB / 1 file
- Download size
- 29 KB
Cite
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Run in R for the authors' preferred citation:
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