Prioritizing Cancer Driver Genes Using Genomics Data
Overview
Cancer genomes contain large numbers of somatic alterations but few genes drive tumor development. Identifying cancer driver genes is critical for precision oncology. Most of current approaches either identify driver genes based on mutational recurrence or using estimated scores predicting the functional consequences of mutations. 'driveR' is a tool for personalized or batch analysis of genomic data for driver gene prioritization by combining genomic information and prior biological knowledge. As features, 'driveR' uses coding impact metaprediction scores, non-coding impact scores, somatic copy number alteration scores, hotspot gene/double-hit gene condition, 'phenolyzer' gene scores and memberships to cancer-related KEGG pathways. It uses these features to estimate cancer-type-specific probability for each gene of being a cancer driver using the related task of a multi-task learning classification model. The method is described in detail in Ulgen E, Sezerman OU. 2021. driveR: driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. BMC Bioinformatics doi:10.1186/s12859-021-04203-7.
Major Changes
- added support for gene-level SCNA data frames to be used as input for
create_features_df()and added an example gene-level SCNA data frameexample_gene_scna_table
Minor changes and bug fixes
- Moved
org.Hs.eg.db,TxDb.Hsapiens.UCSC.hg19.knownGeneandTxDb.Hsapiens.UCSC.hg38.knownGenefrom "Imports" to "Suggests" per new CRAN policy. Relevant functions raise error if the required package is not installed.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-27
- ERROR12 OK, 1 ERROR2026-06-21
- OK13 OK2026-06-09
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- ERROR12 OK, 1 ERROR2026-06-08
- OK13 OK2026-05-10
- ERROR12 OK, 1 ERROR2026-05-03
- OK13 OK2026-05-02
- ERROR11 OK, 1 ERROR2026-04-25
- NOTE11 OK, 3 NOTE2026-04-16
- ERROR10 OK, 3 NOTE, 1 ERROR2026-04-09
- NOTE11 OK, 3 NOTE2026-03-10
Documentation
- Help pages
- 17includes a package overview page
- Examples that run
- 100%2 run in a plain check
- Exported functions with examples
- 67%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
- How to use driveR HTML
Downloads
Repository
- PRs merged (all time)
- 100%
- Median days to close, 50 most recently updated closed issues
- 0
- Median days to close, 50 most recently updated closed PRs
- 0
Stars over time
Forks over time
Releases over time
Issues over time
9 development-tooling and community-health practices detected across 5 families in the upstream repository
Checks run against github.com/egeulgen/driver on 2026-10-22.
The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel
GitHub Pages site last deployed 2025-12-22 · The repository has a site deploy workflow
pkgdown site last built 2025-12-22
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Dependencies
Installing driveR adds 64 packages (35 with compiled code, 48 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, data.table 5.7 MB. 4 more not on CRAN are not measured.
Code & Tests
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People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- 0.5.0Latest
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 0.4.12023-08-19 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 0.4.02022-08-15 · diff ↗
- RR 4.2.0 released · 2022-04-22
- 0.3.02022-01-18 · diff ↗
- RR 4.1.0 released · 2021-05-18
- 0.2.12020-11-26 · diff ↗
- 0.2.02020-11-19 · diff ↗
- 0.1.12020-11-18
- RR 4.0.0 released · 2020-04-24
Package metadata
- First published
- 2020-11-18
- Total releases
- 7 / 6 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 4.0
- Bundled data
- 1.5 MB / 8 files
- Download size
- 2.6 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("driveR")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1186/s12859-021-04203-7.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-24, which the citation names so these numbers can be found later. More on citing and the projects behind them.