Infer Cell-Cell Communication from Spatial Transcriptomics
Overview
Identifies cell-cell communication hotspots in spatial transcriptomics data using bivariate Local Moran's I statistics on hexagonally binned cells. Provides functions for spatial weighting, ligand-receptor pair filtering, hotspot detection, and visualisation of sender-receiver cell-type interactions.
blisa()now uses thefastLISAC/OpenMP backend by default (fast = TRUE) for the bivariate local Moran's I computation.fastLISAmoved from Suggests to Imports. Results are statistically equivalent to the previousspdep::localmoran_bvbackend but not bit-identical (different RNG).- New
min_total_countsargument toblisa()andhexBinCells()drops bins whose total counts (summed over all genes) fall below the threshold during binning. Default10. - New
verboseargument (defaultFALSE) toblisa()andhexBinCells()gates progress messages;blisa()also shows a progress bar over the ligand-receptor pairs in interactive sessions. - New
lr_pairsargument toplotCCI()selects specific ligand-receptor pairs to display, overridingtop_lr.
Show all changes in 1.0.0Hide the rest of the changes in 1.0.0
- New
mainargument toplotCCI(),plotCCILR(), andplotCCIsummary()adds a title above the heatmap.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- OK7 OK2026-06-03
Documentation
- Help pages
- 14 (1 internal)includes a package overview page
- Examples that run
- 8%1 run in a plain check · 11 never run
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Repository
Issues over time
4 development-tooling and community-health practices detected across 2 families in the upstream repository
Checks run against github.com/chenlaboratory/blisa on 2026-10-11.
GitHub Pages site last deployed 2026-08-11 · The repository has a site deploy workflow
pkgdown site last built 2026-08-11
Dependencies
Installing blisa adds 31 packages (19 with compiled code, 43 MB of source tarballs). Heaviest: sf 9.3 MB, ggplot2 6.0 MB, spdep 4.5 MB. 3 more not on CRAN are not measured.
Code & Tests
People & History
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- 1.0.0Latest
- 0.2.02026-06-02
- RR 4.6.0 released · 2026-04-24
Package metadata
- First published
- 2026-06-02
- Total releases
- 2 / 1 yrs
- License
- GPL (>= 3) OSI
- Download size
- 1.0 MB
Cite
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