Surrogate Outcome Regression Analysis
Overview
Performs estimation and inference on a partially missing target outcome (e.g. gene expression in an inaccessible tissue) while borrowing information from a correlated surrogate outcome (e.g. gene expression in an accessible tissue). Rather than regarding the surrogate outcome as a proxy for the target outcome, this package jointly models the target and surrogate outcomes within a bivariate regression framework. Unobserved values of either outcome are treated as missing data. In contrast to imputation-based inference, no assumptions are required regarding the relationship between the target and surrogate outcomes. Estimation in the presence of bilateral outcome missingness is performed via an expectation conditional maximization either algorithm. In the case of unilateral target missingness, estimation is performed using an accelerated least squares procedure. A flexible association test is provided for evaluating hypotheses about the target regression parameters. For additional details, see: McCaw ZR, Gaynor SM, Sun R, Lin X: "Leveraging a surrogate outcome to improve inference on a partially missing target outcome" doi:10.1111/biom.13629.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-04-22
- ERROR13 OK, 1 ERROR2026-04-18
- OK14 OK2026-03-10
Documentation
- Help pages
- 38includes a package overview page
- Examples that run
- 50%2 run in a plain check · 2 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Dependencies
Installing SurrogateRegression adds 2 packages (2 with compiled code, 2.8 MB of source tarballs). Heaviest: Rcpp 1.8 MB, RcppArmadillo 1.0 MB.
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 0.6.0.1Latest
- RR 4.3.0 released · 2023-04-21
- 0.6.02022-08-05 · diff ↗ ·
removed 7 exports
Fit.BNEM, Fit.BNLS, Fit.BNR, Score.BNEM, Test.BNR, Wald.BNEM, Wald.BNLSadded 2 exports
FitBNR, TestBNR - RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 0.5.02020-12-03
- RR 4.0.0 released · 2020-04-24
Package metadata
- First published
- 2020-12-03
- Total releases
- 3 / 6 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 3.4.0
- Download size
- 449 KB
Cite
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