Concentration-Response Data Analysis using Curvep
Overview
An R interface for processing concentration-response datasets using Curvep, a response noise filtering algorithm. The algorithm was described in the publications (Sedykh A et al. (2011) doi:10.1289/ehp.1002476 and Sedykh A (2016) doi:10.1007/978-1-4939-6346-1_14). Other parametric fitting approaches (e.g., Hill equation) are also adopted for ease of comparison. 3-parameter Hill equation from 'tcpl' package (Filer D et al., doi:10.1093/bioinformatics/btw680) and 4-parameter Hill equation from Curve Class2 approach (Wang Y et al., doi:10.2174/1875397301004010057) are available. Also, methods for calculating the confidence interval around the activity metrics are also provided. The methods are based on the bootstrap approach to simulate the datasets (Hsieh J-H et al. doi:10.1093/toxsci/kfy258). The simulated datasets can be used to derive the baseline noise threshold in an assay endpoint. This threshold is critical in the toxicological studies to derive the point-of-departure (POD).
- change: fix a bug in the cal_fit_dataset when doing run_fit with hill bootstrap with a specific direction
- change: add more descriptions on CARR parameter
- change: update the vignette for the parallel computing
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-05-09
- WARNING12 OK, 1 WARNING2026-05-08
- OK14 OK2026-04-06
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- ERROR13 OK, 1 ERROR2026-04-04
- OK14 OK2026-03-10
Documentation
- Help pages
- 20 (1 internal)includes a package overview page
- Examples that run
- 86%12 run in a plain check · 2 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 93%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 10% with a bibliography file
Downloads
Repository
- PRs merged (all time)
- 100%
- Median days to close, 50 most recently updated closed issues
- 1,124
- Median days to close, 50 most recently updated closed PRs
- 0
Issues over time
8 development-tooling and community-health practices detected across 5 families in the upstream repository
Checks run against github.com/moggces/rcurvep on 2026-10-21.
The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel
GitHub Pages site last deployed 2025-05-28 · The repository has a site deploy workflow
pkgdown site last built 2025-06-04
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Dependencies
Code & Tests
Datasets
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- 1.3.2Latest
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.3.1
- RR 4.3.0 released · 2023-04-21
- 1.2.12022-08-25 · diff ↗
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 1.2.02021-01-07
- RR 4.0.0 released · 2020-04-24
Package metadata
- First published
- 2021-01-07
- Total releases
- 4 / 5 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 3.5
- Bundled data
- 588 KB / 4 files
- Download size
- 5.5 MB
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