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Protein Structure Guided Local Test

0packages depend
6.1Kdownloads / year
–test coverage
13/13flavors OK

Overview

About

Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) doi:10.1371/journal.pcbi.1006722.

Changes in 1.4

Changes:

  • Added author@R field in DESCRIPTION

From NEWS in the release

Install

Health

CRAN checks
13OK
Slowest check: 1.5 min · r-oldrel-windows-x86_64
Status changes
  • OK13 OK2026-08-05
  • NOTE12 OK, 1 NOTE2026-08-01
  • OK14 OK2026-03-10
Advisories

none known

Documentation

In release 1.4
READMENoVignettesNoNEWSYes · 33% structured · mentions 1.4Citation fileNoWebsitenot declared in DESCRIPTION
Help pages
1
Examples that run
100%1 run in a plain check
Exported functions with examples
100%
Documented parameters
100%
Return-value docs
100%
Help pages citing references
0%

Downloads

6.1K
CRAN downloads in the past year
Rank #10,294 · ~17/day · ~507/mo
Daily download trend is not available in this view yet.
36730 days
1K90 days
6.1K1 year
Compare downloads with other packages →
Also on72 r2u3 autocran

Dependencies

Declared dependencies
2 external dependencies (excludes base and recommended)

Installing POINT adds 5 packages (4 with compiled code, 3.7 MB of source tarballs). Heaviest: Rcpp 1.8 MB, RcppEigen 1.7 MB, RSpectra 125 KB.

Depends (5)
methodsstatsrARPACKMatrixCompQuadForm
Imports (0)
none
LinkingTo (0)
none
Suggests (0)
none
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (2)
Author, Maintainer since 1.1 (2019)
Listed in earlier versions (2)
Holloway
no longer listed · 1.4
West
no longer listed · 1.4
Releases (4)

Pick two releases to compare their code metrics.

  • R
    R 4.6.0 released · 2026-04-24
  • 1.4Latest
    record
    2025-05-04 · current release · diff ↗
  • R
    R 4.5.0 released · 2025-04-11
  • R
    R 4.4.0 released · 2024-04-24
  • 1.3
    record
    2023-10-01 · diff ↗
  • R
    R 4.3.0 released · 2023-04-21
  • 1.2
    record
    2022-06-07 · diff ↗
  • R
    R 4.2.0 released · 2022-04-22
  • R
    R 4.1.0 released · 2021-05-18
  • R
    R 4.0.0 released · 2020-04-24
  • R
    R 3.6.0 released · 2019-04-26
  • 1.1
    record
    2019-03-05
  • R
    R 3.5.0 released · 2018-04-23

Package metadata

First published
2019-03-05
Total releases
4 / 7 yrs
License
GPL-2 OSI
Download size
11 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("POINT")
Holloway, S. T., & West, R. M. (2025). POINT: Protein Structure Guided Local Test (Version 1.4) [Computer software]. https://doi.org/10.32614/CRAN.package.POINT

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for POINT version 1.4 [Data set]. HJJB, LLC. Data release v2026-10-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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