Group-Sequential Procedures with Multiple Hypotheses
Overview
It is often challenging to strongly control the family-wise type-1 error rate in the group-sequential trials with multiple endpoints (hypotheses). The inflation of type-1 error rate comes from two sources (S1) repeated testing individual hypothesis and (S2) simultaneous testing multiple hypotheses. The 'MultiGroupSequential' package is intended to help researchers to tackle this challenge. The procedures provided include the sequential procedures described in Luo and Quan (2023) doi:10.1080/19466315.2023.2191989 and the graphical procedure proposed by Maurer and Bretz (2013) doi:10.1080/19466315.2013.807748. Luo and Quan (2013) describes three procedures, and the functions to implement these procedures are (1) seqgspgx() implements a sequential graphical procedure based on the group-sequential p-values; (2) seqgsphh() implements a sequential Hochberg/Hommel procedure based on the group-sequential p-values; and (3) seqqvalhh() implements a sequential Hochberg/Hommel procedure based on the q-values. In addition, seqmbgx() implements the sequential graphical procedure described in Maurer and Bretz (2013).
- Minor changes in
graphical()andupdategraph() - Use roxygen2 for documentation and NAMESPACE.
- Add README for installation instructions and basic usage.
- Update DESCRIPTION to remove unnecessary fields and dependencies.
- Add a
NEWS.mdfile to track changes to the package.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK12 OK2026-04-25
- ERROR13 OK, 1 ERROR2026-03-10
Documentation
- Help pages
- 15 (1 internal)includes a package overview page
- Examples that run
- 100%14 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 68%
- Return-value docs
- 100%
- Help pages citing references
- 7%
Downloads
Dependencies
Installing MultiGroupSequential adds 13 packages (11 with compiled code, 28 MB of source tarballs). Heaviest: BH 14 MB, OpenMx 3.7 MB, StanHeaders 2.5 MB.
Code & Tests
People & History
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- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.1.0Latest
- 1.0.02023-05-22
- RR 4.3.0 released · 2023-04-21
Package metadata
- First published
- 2023-05-22
- Total releases
- 2 / 3 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 4.0.0
- Download size
- 16 KB
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