Genotype-Specific Survival Estimation
Overview
We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.
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NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Baosheng Liang <liangbsunc@gmail.com>’
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Authors@R: c(person(given = "Baosheng",
family = "Liang",
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email = "liangbsunc@gmail.com"),
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family = "Wang",
role = "aut"),
person(given = "Donglin",
family = "Zeng",
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as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
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Maintainer since 0.1 (2015)
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- RR 3.4.0 released · 2017-04-21
- RR 3.3.0 released · 2016-05-03
- 0.1Latest2015-10-20 · current release
- RR 3.2.0 released · 2015-04-16
Package metadata
- First published
- 2015-10-20
- Total releases
- 1 / 11 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 3.0.1
- Bundled data
- 2.9 KB / 2 files
- Download size
- 14 KB
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