Misspecified Models for Gene-Environment Interaction
Overview
The first major functionality is to compute the bias in regression coefficients of misspecified linear gene-environment interaction models. The most generalized function for this objective is GE_bias(). However GE_bias() requires specification of many higher order moments of covariates in the model. If users are unsure about how to calculate/estimate these higher order moments, it may be easier to use GE_bias_normal_squaredmis(). This function places many more assumptions on the covariates (most notably that they are all jointly generated from a multivariate normal distribution) and is thus able to automatically calculate many of the higher order moments automatically, necessitating only that the user specify some covariances. There are also functions to solve for the bias through simulation and non-linear equation solvers; these can be used to check your work. Second major functionality is to implement the Bootstrap Inference with Correct Sandwich (BICS) testing procedure, which we have found to provide better finite-sample performance than other inference procedures for testing GxE interaction. More details on these functions are available in Sun, Carroll, Christiani, and Lin (2018) doi:10.1111/biom.12813.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- OK14 OK2026-03-10
Documentation
- Help pages
- 7 (2 internal)
- Examples that run
- 100%7 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 98%
- Return-value docs
- 100%
- Help pages citing references
- 0%
- GEint Tutorial HTML
Downloads
Dependencies
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- unarchivedReturned to CRAN2025-10-01
- 1.1Latest2025-10-01 · current release · diff ↗ ·
removed 9 exports
GE_BICS_old, GE_bias_normal_squaredmis_old, GE_bias_old, GE_enumerate_inputs, GE_enumerate_inputs_old, GE_nleqslv_old, GE_scoreeq_sim_old, GE_test_moment_calcs_old, GE_translate_inputs_old - RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- archivedRemoved from CRAN2023-03-31requires archived package 'speedglm'
- unarchivedReturned to CRAN2022-05-18
- 1.02022-05-18 · diff ↗
- archivedRemoved from CRAN2022-05-09check problems were not corrected despite reminders
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- 0.1.52019-01-15 · diff ↗
- RR 3.5.0 released · 2018-04-23
Show 5 earlier eventsHide 5 earlier events
- 0.1.42017-08-09 · diff ↗ ·
added 8 exports
GE_BICS_old, GE_bias_normal_squaredmis_old, GE_bias_old, GE_enumerate_inputs_old, GE_nleqslv_old, GE_scoreeq_sim_old, GE_test_moment_calcs_old, GE_translate_inputs_old - RR 3.4.0 released · 2017-04-21
- 0.1.22017-01-06 · diff ↗
- 0.1.12016-10-01
- RR 3.3.0 released · 2016-05-03
Package metadata
- First published
- 2016-10-01
- Total releases
- 6 / 10 yrs
- License
- GPL-3 OSI
- Download size
- 60 KB
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