R Observatory: Metrics for BOIN version 2.7.2

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

BOIN

2.7.2

Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials

4packages depend

7.7Kdownloads / year

–test coverage

11/13checks pass

Overview

About

Maintained by Ying YuanFirst published 2014-09-1921 releasesCRAN page ↗

The Bayesian optimal interval (BOIN) design is a novel phase I clinical trial design for finding the maximum tolerated dose (MTD). It can be used to design both single-agent and drug-combination trials. The BOIN design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. The prominent advantage of the BOIN design is that it achieves simplicity and superior performance at the same time. The BOIN design is algorithm-based and can be implemented in a simple way similar to the traditional 3+3 design. The BOIN design yields an average performance that is comparable to that of the continual reassessment method (CRM, one of the best model-based designs) in terms of selecting the MTD, but has a substantially lower risk of assigning patients to subtherapeutic or overly toxic doses. For tutorial, please check Yan et al. (2020) doi:10.18637/jss.v094.i13.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("BOIN", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-boin

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-BOIN

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-BOIN

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

2NOTE11OK

Failing flavors

NOTE r-devel-linux-x86_64-debian-clang
NOTE r-devel-linux-x86_64-debian-gcc

Slowest check: 1.2 min · r-devel-windows-x86_64

Code health

None

Tests · ratio 0.00

not tracked

Coverage

100%

Documentation · exports

1

Dependencies · direct

Check history

NOTE2026-03-10
12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMENoVignettesNopkgdown siteNoNEWSNoCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: 100%
Return-value docs: 100%
References docs: 70%

Downloads

7.7K

CRAN downloads in the past year

Rank #5,126 · ~21/day · ~639/mo

Releases R versions

Daily download trend is not available in this view yet.

40830 days

1.5K90 days

7.7K1 year

Compare downloads with other packages →

Also on155 r2u52 autocran72 c2d4u

Dependencies

Declared dependencies

1 external dependency (excludes base and recommended)

Depends (0)

none

Imports (1)

Iso

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

4direct

0indirect

SEARS bfboin bfboinet escalation

Code & Tests

People & History

People (0)

Author records are not tracked yet for this package.

Listed in earlier versions (2)

Suyu Liu

no longer listed · 1.0 to 2.7.2

Ying Yuan

no longer listed · 1.0 to 2.7.2

Package Timeline

21 releases. Pick two to compare their code metrics. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
R
R 4.4.0 released · 2024-04-24
R
R 4.3.0 released · 2023-04-21
R
R 4.2.0 released · 2022-04-22
R
R 4.1.0 released · 2021-05-18
2.7.2Latest
2021-01-19 · current release · diff ↗
2.7.1
2020-11-19 · diff ↗
2.7.0
2020-09-29 · diff ↗
2.6.9
2020-09-01 · diff ↗
2.6.8
2020-06-30 · diff ↗
2.6.7
2020-06-06 · diff ↗
2.6.6
2020-05-23 · diff ↗
2.6.5
2020-05-20 · diff ↗
R
R 4.0.0 released · 2020-04-24
R
R 3.6.0 released · 2019-04-26

Show 18 earlier events

2.6.4
2018-10-12 · diff ↗
R
R 3.5.0 released · 2018-04-23
2.6.3
2018-04-10 · diff ↗
2.6.2
2018-03-27 · diff ↗
2.6.1
2018-03-16 · diff ↗
2.6
2018-02-21 · diff ↗
R
R 3.4.0 released · 2017-04-21
2.4
2016-08-09 · diff ↗
2.3
2016-05-29 · diff ↗
R
R 3.3.0 released · 2016-05-03
2.2
2016-04-22 · diff ↗
2.1
2016-03-02 · diff ↗
2.0
2015-09-04 · diff ↗
1.2
2015-07-28 · diff ↗
R
R 3.2.0 released · 2015-04-16
1.1
2015-02-15 · diff ↗
1.0
2014-09-19
R
R 3.1.0 released · 2014-04-10

Package metadata

First published: 2014-09-19
Total releases: 21 / 12 yrs
License: GPL-2 OSI
Download size: 38 KB
Installed size: not tracked yet
With dependencies: not tracked yet

Appears in task views

Clinical Trial Design, Monitoring, Analysis and Reporting Design of Experiments (DoE) & Analysis of Experimental Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("BOIN")

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for BOIN version 2.7.2 [Data set]. HJJB, LLC. Data release v2026-08-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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