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Methods to Impute and Analyze Data with BLOQ Observations

0packages depend
6.5Kdownloads / year
63.4%test coverage
13/13flavors OK

Overview

About

Provides methods for estimating the area under the concentration versus time curve (AUC) and its standard error in the presence of Below the Limit of Quantification (BLOQ) observations. Two approaches are implemented: direct estimation using censored maximum likelihood, and a two-step approach that first imputes BLOQ values using various methods and then computes the AUC using the imputed data. Technical details are described in Barnett et al. (2020), "Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification," Statistics in Biopharmaceutical Research. doi:10.1080/19466315.2019.1701546.

Install

Health

CRAN checks
13OK
Slowest check: 1.2 min · r-oldrel-windows-x86_64
Status changes
  • OK13 OK2026-08-05
  • NOTE12 OK, 1 NOTE2026-08-01
  • OK14 OK2026-03-10
Advisories

none known

Documentation

In release 0.1-2
READMENoVignettesNoNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION
Help pages
12
Examples that run
100%12 run in a plain check
Exported functions with examples
100%
Documented parameters
100%
Return-value docs
100%
Help pages citing references
0%

Downloads

6.5K
CRAN downloads in the past year
Rank #7,267 · ~18/day · ~541/mo
Daily download trend is not available in this view yet.
38730 days
1.2K90 days
6.5K1 year
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Also on96 r2u18 autocran66 c2d4u

Dependencies

Declared dependencies
3 external dependencies (excludes base and recommended)

Installing BLOQ adds 7 packages (3 with compiled code, 4.1 MB of source tarballs). Heaviest: sandwich 1.4 MB, mvtnorm 1.0 MB, maxLik 791 KB.

Depends (0)
none
Imports (2)
LinkingTo (0)
none
Suggests (1)
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (5)
Maintainer since 0.1-0 (2018)
Releases (3)

Pick two releases to compare their code metrics.

  • R
    R 4.6.0 released · 2026-04-24
  • 0.1-2Latest
    record
    2025-05-05 · current release · diff ↗
  • R
    R 4.5.0 released · 2025-04-11
  • R
    R 4.4.0 released · 2024-04-24
  • R
    R 4.3.0 released · 2023-04-21
  • R
    R 4.2.0 released · 2022-04-22
  • R
    R 4.1.0 released · 2021-05-18
  • unarchivedReturned to CRAN
    2020-06-07
  • 0.1-1
    record
    2020-06-07 · diff ↗
  • archivedRemoved from CRAN
    2020-05-14
    it requires package 'mvmle' Which was orphaned and is now archived
  • R
    R 4.0.0 released · 2020-04-24
  • R
    R 3.6.0 released · 2019-04-26
  • 0.1-0
    record
    2018-08-13
  • R
    R 3.5.0 released · 2018-04-23

Package metadata

First published
2018-08-13
Total releases
3 / 8 yrs
License
GPL (>= 2) OSI
Download size
19 KB
Appears in task views

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("BLOQ")
Nassiri, V., Barnett, H., Geys, H., Jacobs, T., & Jaki, T. (2025). BLOQ: Methods to Impute and Analyze Data with BLOQ Observations (Version 0.1-2) [Computer software]. https://doi.org/10.32614/CRAN.package.BLOQ

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for BLOQ version 0.1-2 [Data set]. HJJB, LLC. Data release v2026-10-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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