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Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al.

Full description

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the 'R' console with sgRNA_Design() or through 'crispRdesignR's' user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

Maintainer
Dylan Beeber
Licence
GPL-3
Latest release
12 Apr 2023
First release
26 May 2020

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More details
Releases
3
Needs compilation
No
Needs R
>= 2.10
RoxygenNote
7.1.0
Task views (0)

Earlier: Genomics, Proteomics, Metabolomics, Transcriptomics, and Other Omics (until 22 Dec 2022).

Subjects (1) Method, Subjects
Cite

Package

Run in R for the authors' preferred citation:

citation("crispRdesignR")
APA
Beeber, D., & Chain, F. (2023). crispRdesignR: Guide Sequence Design for CRISPR/Cas9 (Version 1.1.7) [Computer software]. https://doi.org/10.32614/CRAN.package.crispRdesignR
About

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA
Balamuta, J. J. (2026). R Observatory: Metrics for crispRdesignR version 1.1.7 [Data set]. HJJB, LLC. Data release v2026-10-28. https://doi.org/10.5281/zenodo.21843040
About

From data release v2026-10-28, which the citation names so these numbers can be found later.

No warnings or errors. 2 of 13 check platforms have notes.

  • r-devel-linux-x86_64-fedora-clang

    The unreleased R on Linux, x86_64, fedora-clang

    Note

    Version checked
    1.1.7
    Time taken
    40 s

    dependencies in R code: Note

    Namespace in Imports field not imported from:

    Full output

  • r-devel-linux-x86_64-fedora-gcc

    The unreleased R on Linux, x86_64, fedora-gcc

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    Version checked
    1.1.7
    Time taken
    39 s

    dependencies in R code: Note

    Namespace in Imports field not imported from:

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  • r-devel-linux-x86_64-debian-clang

    The unreleased R on Linux, x86_64, debian-clang

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    1.1.7
    Time taken
    59 s
  • r-devel-linux-x86_64-debian-gcc

    The unreleased R on Linux, x86_64, debian-gcc

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  • r-devel-windows-x86_64

    The unreleased R on Windows, x86_64

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    1.1.7
    Time taken
    90 s
  • r-oldrel-macos-arm64

    The previous release of R on macOS, arm64

    OK

    Version checked
    1.1.7
  • r-oldrel-macos-x86_64

    The previous release of R on macOS, x86_64

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    1.1.7
    Time taken
    46 s
  • r-oldrel-windows-x86_64

    The previous release of R on Windows, x86_64

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    1.1.7
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    88 s
  • r-patched-linux-x86_64

    The patched release of R on Linux, x86_64

    OK

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    1.1.7
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    53 s
  • r-release-linux-x86_64

    The current release of R on Linux, x86_64

    OK

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    1.1.7
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    54 s
  • r-release-macos-arm64

    The current release of R on macOS, arm64

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    1.1.7
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  • r-release-macos-x86_64

    The current release of R on macOS, x86_64

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  • r-release-windows-x86_64

    The current release of R on Windows, x86_64

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  • 2 Note
  • 11 OK
Check output (1)

dependencies in R code, Note on 2 platforms

Namespace in Imports field not imported from:
  ‘DT’
All declared Imports should be used.

Over time

No change since 9 Jun 2026

As a list (5)
ChangedWorst statusOKNotesWarningsErrors
9 Jun 2026Note11200
8 Jun 2026Error10201
10 May 2026Note11200
3 May 2026Error10201
10 Mar 2026Note10400

Since March 2026

Check results on CRAN

Total downloads in the last 30 days
423−26.1% down on the 30 days before, the worse directionIt is the sum of 2 channels: CRAN and r2u.

CRAN rank

8,889 of 26,530

CRAN

388 downloads in the last 30 days

Rank
8,889 of 26,530
Change
−31.2% down on the 30 days before, the worse direction

It is in the total. Take it out

r2u

35 downloads in the last 30 days

Rank
3,687 of 30,526
Change
+338% up on the 30 days before, the better direction

It is in the total. Take it out

Over time

Compare downloads

Needs
12
Dependent packages
0
Suggested by
0
Needs (12)
Installing it adds
47 packages, 46.1 MB of source
Of those, need compilation
25
Optional extras (1)
Functions
6
Public exports
6
Lines of R code
1,272
Median complexity
15.5
Functions (6)
Size and composition

Lines by kind (1,502)

KindLinesShare
R code1,27285%
Documentation23015%

Lines by language

LanguageLinesShare
R1,27285%
Rd23015%

Languages are counted from file extensions.

Files
22
R functions
6
Complexity
Median
15.5
Mean
24.5
Highest
58
Median lines per function
133
About complexity

Cyclomatic complexity counts the independent paths through a function: 1 is a straight line, higher is harder to test. R functions only.

Call graph figures
R functions
6
Calls
2
Unconnected
3
Groups
1
Growth (3 releases)
Total lines by release
1,502 on 26 May 20201,502 on 12 Apr 2023
Release changes

The package was built and has no tests to run.

Lines of tests
0
Exports named in tests
0%
Test suite
Has tests
No
Test frameworks
No tests in this release
Test lines per line of code
0
Exports documented
100%
Arguments documented
100%
Return value documented
100%
Help pages with examples
66.7%
Examples run in checks
100%
Other documentation
README
Yes, 749 words
Release notes file
No
Help pages
6
Lines of documentation
230

2 datasets, 0 can be loaded by name

DatasetSizeColumns
CFD_Model_Scores240 × 4sgRNA, DNA, Position, Score
Rule_Set_2_Modellength 27

dylanbeeber / crisprdesignr on github.com

Stars
16no change on 30 days ago
Forks
9
Open issues
6
Last commit
13 Apr 2023
Activity
Commits
277
Open pull requests
0
Tagged releases
0
Latest tagged release
–
Issues closed in
17 days (median)
Pull requests closed in
–
Pull requests merged
–
Created
28 May 2018
Licence file reads as
–
R releases
  • On CRAN
  • Archived
  • Release
1.1.51.1.61.1.7BackArchivedArchivedArchived and back

Archived and back

ArchivedBackCRAN's reasonKind
19 Dec 202212 Apr 2023issues were not corrected in timeChecks not fixed
VersionReleasedREvents
1.1.7 current12 Apr 20234.2.3Back on CRAN 12 Apr 2023
1.1.611 Jan 20214.0.3Archived 19 Dec 2022
“issues were not corrected in time”
1.1.526 May 20204.0.0