Diagnostics for Nonlinear Mixed-Effect Models
Overview
A model building aid for nonlinear mixed-effects (population) model analysis using NONMEM, facilitating data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison. The methods are described in Keizer et al. (2013) doi:10.1038/psp.2013.24, and Jonsson et al. (1999) doi:10.1016/s0169-2607(98)00067-4.
- Cross-references to other R packages in documentation have been updated according to R standards.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-04
- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- OK14 OK2026-03-10
Documentation
- Help pages
- 161 (9 internal)includes a package overview page
- Examples that run
- 58%65 run in a plain check · 47 never run
- Exported functions with examples
- 75%
- Documented parameters
- 96%
- Return-value docs
- 83%
- Help pages citing references
- 2%
Downloads
Repository
- PRs merged (all time)
- 86%
- Median days to close, 50 most recently updated closed issues
- 119
- Median days to close, 50 most recently updated closed PRs
- 9
Stars over time
Forks over time
Releases over time
Issues over time
PRs over time
10 development-tooling and community-health practices detected across 6 families in the upstream repository
Checks run against github.com/uupharmacometrics/xpose4 on 2026-10-11.
The R CMD check workflow runs on Linux, macOS and Windows, and on R-devel
GitHub Pages site last deployed 2025-09-05 · The repository has a site deploy workflow
pkgdown site last built 2025-09-03
Show all practicesHide 2 practices
Dependencies
Installing xpose4 adds 72 packages (37 with compiled code, 57 MB of source tarballs). Heaviest: stringi 11 MB, ggplot2 6.0 MB, data.table 5.7 MB.
Code & Tests
Datasets
People & History
Maintainer since 4.3.0 (2010)
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- 4.7.4Latest
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 4.7.32024-02-22 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 4.7.22022-05-31 · diff ↗
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- unarchivedReturned to CRAN2020-12-18
- 4.7.12020-12-18 · diff ↗
- archivedRemoved from CRAN2020-12-10check problems were not corrected in time
- RR 4.0.0 released · 2020-04-24
- 4.7.02020-02-27 · diff ↗
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
Show 18 earlier eventsHide 18 earlier events
- 4.6.1
- 4.6.02017-06-17 · diff ↗ ·
removed 1 export
pattern:^[^\\.]added 198 exports
Data<-, SData<-, change.cat.cont<-, change.cat.levels<-, change.dv.cat.levels<-, xlabel<-, xsubset<-, xvardef<-, Data, SData, absval.cwres.vs.cov.bw, absval.cwres.vs.pred, absval.cwres.vs.pred.by.cov, absval.dcwres.vs.cov.model.comp, absval.dipred.vs.cov.model.comp, absval.diwres.vs.cov.model.comp, absval.dpred.vs.cov.model.comp, absval.dwres.vs.cov.model.comp, absval.iwres.cwres.vs.ipred.pred, absval.iwres.vs.cov.bw, absval.iwres.vs.idv, absval.iwres.vs.ipred, absval.iwres.vs.ipred.by.cov, absval.iwres.vs.pred, absval.iwres.wres.vs.ipred.pred, absval.wres.vs.cov.bw, absval.wres.vs.idv, absval.wres.vs.pred, absval.wres.vs.pred.by.cov, add.absval and 168 more - RR 3.4.0 released · 2017-04-21
- RR 3.3.0 released · 2016-05-03
- RR 3.2.0 released · 2015-04-16
- 4.5.32014-11-24 · diff ↗
- 4.5.02014-05-20 · diff ↗
- RR 3.1.0 released · 2014-04-10
- 4.4.12013-08-13 · diff ↗
- RR 3.0.0 released · 2013-04-03
- 4.4.02012-10-17 · diff ↗
- 4.3.52012-04-19 · diff ↗
- RR 2.15.0 released · 2012-03-30
- RR 2.14.0 released · 2011-10-31
- RR 2.13.0 released · 2011-04-13
- 4.3.22010-11-30 · diff ↗
- 4.3.02010-10-23
- RR 2.12.0 released · 2010-10-15
Package metadata
- First published
- 2010-10-23
- Total releases
- 14 / 16 yrs
- License
- LGPL (>= 3) OSI
- Copyright
- 2009-2025 Andrew C. Hooker, E. Niclas Jonsson and Mats O. Karlsson. 2005-2008 Andrew C. Hooker, Justin J. Wilkins, Mats O. Karlsson and E. Niclas Jonsson. 1998-2004 E. Niclas Jonsson and Mats Karlsson.
- Minimum R
- ≥ 2.2.0
- Bundled data
- 33 KB / 1 file
- Download size
- 608 KB
Cite
Cite this package
Run in R for the authors' entry:
citation("xpose4")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.1016/s0169-2607(98)00067-4, 10.1038/psp.2013.24.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-18, which the citation names so these numbers can be found later. More on citing and the projects behind them.