Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network
Overview
Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at doi:10.1186/s12859-018-2351-7.
Install
Health
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Deisy Morselli Gysi <deisy.ccnr@gmail.com>’
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Authors@R: c(person(given = c("Deisy", "Morselli"),
family = "Gysi",
role = c("aut", "cre"),
email = "deisy.ccnr@gmail.com"),
person(given = "Andre",
family = "Voigt",
role = "aut"),
person(given = c("Tiago", "Miranda"),
family = "Fragoso",
role = "aut"),
person(given = "Eivind",
family = "Almaas",
role = "aut"),
person(given = "Katja",
family = "Nowick.",
role = "aut"))
as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 17 (4 internal)
- Examples that run
- 17%1 run in a plain check · 4 never run · 1 hold no code
- Exported functions with examples
- 67%
- Documented parameters
- 98%
- Return-value docs
- 33%
- Help pages citing references
- 6%
Downloads
Dependencies
Installing wTO adds 46 packages (30 with compiled code, 51 MB of source tarballs). Heaviest: stringi 11 MB, data.table 5.7 MB, bslib 5.6 MB.
Code & Tests
Datasets
People & History
Maintainer since 1.1.0 (2017)
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- unarchivedReturned to CRAN2024-07-05
- 2.1Latest
- RR 4.4.0 released · 2024-04-24
- archivedRemoved from CRAN2024-04-20issues were not corrected despite reminders
- RR 4.3.0 released · 2023-04-21
- 2.0.22023-03-22 · diff ↗
- 2.0.12022-05-24 · diff ↗
- 2.02022-05-11 · diff ↗
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- 1.6.32018-11-17 · diff ↗
- 1.6.2
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Package metadata
- First published
- 2017-05-29
- Total releases
- 16 / 9 yrs
- License
- GPL-2 OSI
- Bundled data
- 149 KB / 4 files
- Download size
- 91 KB
Cite
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citation("wTO")The package provides a citation file that builds its entry when R runs it. Run citation() to see it.
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