Description
A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (6 non-OK)
for GNU extensions in Makefiles
GNU make is a SystemRequirements.
installed package size
installed size is 135.3Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 130.3Mb
for GNU extensions in Makefiles
GNU make is a SystemRequirements.
installed package size
installed size is 127.1Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 122.2Mb
for GNU extensions in Makefiles
GNU make is a SystemRequirements.
installed package size
installed size is 12.0Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 7.0Mb
Check History
NOTE 11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
installed package size
installed size is 135.3Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 130.3Mb
installed package size
installed size is 127.1Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 122.2Mb
installed package size
installed size is 12.0Mb
sub-directories of 1Mb or more:
doc 3.9Mb
libs 7.0Mb