Simulating Oncology Trials using an Illness-Death Model
Overview
Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) doi:10.1002/sim.8295. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
Bug Fixes
corPFSOSnow undoes thefutureplan upon function exit.
Miscellaneous
- Change of maintainer.
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-04
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-10
Documentation
- Help pages
- 60 (8 internal)includes a package overview page
- Examples that run
- 100%52 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 98%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Repository
- PRs merged (all time)
- 99%
- Median days to close, 50 most recently updated closed issues
- 14
- Median days to close, 50 most recently updated closed PRs
- 1
Stars over time
Forks over time
Releases over time
Issues over time
PRs over time
14 development-tooling and community-health practices detected across 7 families in the upstream repository
Checks run against github.com/insightsengineering/simidm on 2026-10-18.
Funding links: pharmaverse.org
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Dependencies
Installing simIDM adds 19 packages (12 with compiled code, 13 MB of source tarballs). Heaviest: data.table 5.7 MB, viridisLite 1.2 MB, vctrs 1.0 MB.
Code & Tests
People & History
Previously maintained by Alexandra Erdmann (0.0.5 to 0.1.0).
Pick two releases to compare their code metrics.
- 0.1.1Latest
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 0.1.02023-12-11 · diff ↗ ·
removed 4 exports
PwcOSInt, WeibOSInteg, getPCWHazard, integrateVectoradded 24 exports
ExpHazOS, ExpQuantOS, avgHRExpOS, avgHRIntegExpOS, corPFSOS, corTrans, empSignificant, estimateParams, expvalOSInteg, expvalPFSInteg, getInit, getPWCHazard, getResults, getTarget, haz, logRankTest, log_p11, negLogLik, passedLogRank, prepareData, survOS, survPFS, survPFSOS, survTrans - RR 4.3.0 released · 2023-04-21
- 0.0.52023-01-27
- RR 4.2.0 released · 2022-04-22
Package metadata
- First published
- 2023-01-27
- Total releases
- 3 / 3 yrs
- License
- Apache License 2.0 OSI
- Minimum R
- ≥ 3.6
- Download size
- 406 KB
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