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sctransform

Variance Stabilizing Transformations for Single Cell UMI Data

v0.4.3 · Jan 9, 2026 · GPL-3 | file LICENSE

Description

A normalization method for single-cell UMI count data using a variance stabilizing transformation. The transformation is based on a negative binomial regression model with regularized parameters. As part of the same regression framework, this package also provides functions for batch correction, and data correction. See Hafemeister and Satija (2019) <doi:10.1186/s13059-019-1874-1>, and Choudhary and Satija (2022) <doi:10.1186/s13059-021-02584-9> for more details.

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package dependencies

Package which this enhances but not available for checking: ‘glmGamPoi’

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NOTE 13 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
NOTE r-oldrel-macos-arm64

package dependencies

Package which this enhances but not available for checking: ‘glmGamPoi’

Reverse Dependencies (5)

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Dependency Network

Dependencies Reverse dependencies dplyr magrittr MASS Matrix future.apply future parallelly ggplot2 reshape2 rlang gridExtra matrixStats Seurat spatialGE RESET SCdeconR VAM sctransform

Version History

new 0.4.3 Mar 10, 2026
updated 0.4.3 ← 0.4.2 diff Jan 9, 2026
updated 0.4.2 ← 0.4.1 diff Apr 29, 2025
updated 0.4.1 ← 0.4.0 diff Oct 18, 2023
updated 0.4.0 ← 0.3.5 diff Sep 18, 2023
updated 0.3.5 ← 0.3.4 diff Sep 20, 2022
updated 0.3.4 ← 0.3.3 diff Aug 20, 2022
updated 0.3.3 ← 0.3.2 diff Jan 12, 2022
updated 0.3.2 ← 0.3.1 diff Dec 15, 2020
updated 0.3.1 ← 0.3 diff Oct 7, 2020
updated 0.3 ← 0.2.1 diff Sep 19, 2020
updated 0.2.1 ← 0.2.0 diff Dec 16, 2019
updated 0.2.0 ← 0.1.0 diff Apr 11, 2019
new 0.1.0 Nov 17, 2018