Single Cell Mapper
Overview
The single cell mapper (scMappR) R package contains a suite of bioinformatic tools that provide experimentally relevant cell-type specific information to a list of differentially expressed genes (DEG). The function "scMappR_and_pathway_analysis" reranks DEGs to generate cell-type specificity scores called cell-weighted fold-changes. Users input a list of DEGs, normalized counts, and a signature matrix into this function. scMappR then re-weights bulk DEGs by cell-type specific expression from the signature matrix, cell-type proportions from RNA-seq deconvolution and the ratio of cell-type proportions between the two conditions to account for changes in cell-type proportion. With cwFold-changes calculated, scMappR uses two approaches to utilize cwFold-changes to complete cell-type specific pathway analysis. The "process_dgTMatrix_lists" function in the scMappR package contains an automated scRNA-seq processing pipeline where users input scRNA-seq count data, which is made compatible for scMappR and other R packages that analyze scRNA-seq data. We further used this to store hundreds up regularly updating signature matrices. The functions "tissue_by_celltype_enrichment", "tissue_scMappR_internal", and "tissue_scMappR_custom" combine these consistently processed scRNAseq count data with gene-set enrichment tools to allow for cell-type marker enrichment of a generic gene list (e.g. GWAS hits). Reference: Sokolowski,D.J., Faykoo-Martinez,M., Erdman,L., Hou,H., Chan,C., Zhu,H., Holmes,M.M., Goldenberg,A. and Wilson,M.D. (2021) Single-cell mapper (scMappR): using scRNA-seq to infer cell-type specificities of differentially expressed genes. NAR Genomics and Bioinformatics. 3(1). Iqab011. doi:10.1093/nargab/lqab011.
Install
Health
ERRORpackage dependenciesr-patched-linux-x86_64
Package required but not available: ‘GSVA’ See section ‘The DESCRIPTION file’ in the ‘Writing R Extensions’ manual.
- ERROR12 OK, 1 ERROR2026-10-15
- WARNING12 OK, 1 WARNING2026-09-25
- OK13 OK2026-09-24
- ERROR12 OK, 1 ERROR2026-09-17
- OK13 OK2026-08-04
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- NOTE12 OK, 1 NOTE2026-08-01
- OK13 OK2026-07-26
- ERROR12 OK, 1 ERROR2026-07-19
- OK13 OK2026-06-27
- ERROR12 OK, 1 ERROR2026-06-21
- OK13 OK2026-06-09
- ERROR12 OK, 1 ERROR2026-06-08
- OK13 OK2026-05-10
- ERROR12 OK, 1 ERROR2026-05-03
- OK13 OK2026-04-30
- ERROR12 OK, 2 ERROR2026-04-09
- OK14 OK2026-03-16
- ERROR13 OK, 1 ERROR2026-03-13
- OK14 OK2026-03-10
Documentation
- Help pages
- 34
- Examples that run
- 38%13 run in a plain check · 21 only when donttest examples are enabled (R CMD check --as-cran)
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Dependencies
Installing scMappR adds 165 packages (94 with compiled code, 143 MB of source tarballs). Heaviest: BH 14 MB, stringi 11 MB, ggplot2 6.0 MB. 3 more not on CRAN are not measured.
Code & Tests
Datasets
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- unarchivedReturned to CRAN2025-06-25
- 1.0.12Latest
- archivedRemoved from CRAN2025-06-02requires archived package 'limSolve'
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.0.112023-06-30 · diff ↗
- RR 4.3.0 released · 2023-04-21
- unarchivedReturned to CRAN2023-02-18
- 1.0.102023-02-18 · diff ↗
- archivedRemoved from CRAN2022-12-21email to the maintainer was undeliverable
- RR 4.2.0 released · 2022-04-22
- 1.0.92022-03-07 · diff ↗
- 1.0.72021-10-16 · diff ↗
- RR 4.1.0 released · 2021-05-18
- 1.0.22021-05-15 · diff ↗
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Package metadata
- First published
- 2020-03-04
- Total releases
- 13 / 6 yrs
- License
- GPL-3 OSI
- Minimum R
- ≥ 4.0.0
- Bundled data
- 529 KB / 5 files
- Download size
- 651 KB
Cite
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