refineR
2.0.0Reference Interval Estimation using Real-World Data
Overview
Indirect method for the estimation of reference intervals (RIs) using Real-World Data ('RWD') and methods for comparing and verifying RIs. Estimates RIs by applying advanced statistical methods to routine diagnostic test measurements, which include both pathological and non-pathological samples, to model the distribution of non-pathological samples. This distribution is then used to derive reference intervals and support RI verification, i.e., deciding if a specific RI is suitable for the local population. The package also provides functions for printing and plotting algorithm results. See ?refineR for a detailed description of features. Version 1.0 of the algorithm is described in 'Ammer et al. (2021)' doi:10.1038/s41598-021-95301-2. Additional guidance is in 'Ammer et al. (2023)' doi:10.1093/jalm/jfac101. The verification method is described in 'Beck et al. (2025)' doi:10.1515/cclm-2025-0728.
Install
Health
- OK2026-08-0513 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
- NOTE2026-08-0112 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
- OK2026-06-0913 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
- WARNING2026-06-0812 OK · 0 NOTE · 1 WARNING · 0 ERROR · 0 FAILURE
- OK2026-04-2512 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
Show 1 earlier snapshots
- NOTE2026-03-1011 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
Documentation
- Examples that run
- 13%
- Documented parameters
- 100%
- Return-value docs
- 100%
- References docs
- 7%
Downloads
Dependencies
Nothing depends on this yet.
Code & Tests
Datasets
People & History
7 releases. Pick two to compare their code metrics. R releases are shown for context.
- RR 4.6.0 released · 2026-04-24
- 2.0.0Latest
- RR 4.5.0 released · 2025-04-11
- 1.6.22024-08-21 · diff ↗
- RR 4.4.0 released · 2024-04-24
- 1.6.12023-11-14 · diff ↗
- RR 4.3.0 released · 2023-04-21
- 1.6.02023-03-08 · diff ↗
- 1.5.12022-07-19 · diff ↗
- 1.5.02022-06-03 · diff ↗
- RR 4.2.0 released · 2022-04-22
- 1.0.02021-08-02
- RR 4.1.0 released · 2021-05-18
Package metadata
- First published
- 2021-08-02
- Total releases
- 7 / 5 yrs
- License
- GPL (>= 3) OSI
- Minimum R
- ≥ 3.2.0
- Bundled data
- 3.5 MB / 5 files
- Download size
- 4.3 MB
- Installed size
- not tracked yet
- With dependencies
- not tracked yet
Cite
Cite this package
Run in R for the authors' preferred citation:
citation("refineR")This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-08-24, which the citation names so these numbers can be found later. More on citing and the projects behind them.