pssmooth
1.0.3Flexible and Efficient Evaluation of Principal Surrogates/Treatment Effect Modifiers
Overview
Implements estimation and testing procedures for evaluating an intermediate biomarker response as a principal surrogate of a clinical response to treatment (i.e., principal stratification effect modification analysis), as described in Juraska M, Huang Y, and Gilbert PB (2020), Inference on treatment effect modification by biomarker response in a three-phase sampling design, Biostatistics, 21(3): 545-560 doi:10.1093/biostatistics/kxy074. The methods avoid the restrictive 'placebo structural risk' modeling assumption common to past methods and further improve robustness by the use of nonparametric kernel smoothing for biomarker density estimation. A randomized controlled two-group clinical efficacy trial is assumed with an ordered categorical or continuous univariate biomarker response measured at a fixed timepoint post-randomization and with a univariate baseline surrogate measure allowed to be observed in only a subset of trial participants with an observed biomarker response (see the flexible three-phase sampling design in the paper for details). Bootstrap-based procedures are available for pointwise and simultaneous confidence intervals and testing of four relevant hypotheses. Summary and plotting functions are provided for estimation results.
Install
Health
- NOTE r-devel-linux-x86_64-debian-clang
- NOTE r-devel-linux-x86_64-debian-gcc
- NOTE2026-06-0911 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
- ERROR2026-06-0811 OK · 1 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
- NOTE2026-03-109 OK · 5 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
Documentation
- Examples that run
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- References docs
- 83%
Downloads
Repository
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Checks run against github.com/mjuraska/pssmooth on 2026-08-09.
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Dependencies
Nothing depends on this yet.
Code & Tests
People & History
4 releases. Pick two to compare their code metrics. R releases are shown for context.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- 1.0.3Latest
- unarchivedReturned to CRAN2020-11-18
- archivedRemoved from CRAN2020-10-18requires archived package 'osDesign'
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- 1.0.22019-01-22 · diff ↗
- 1.0.12018-09-19 · diff ↗
- 1.0.02018-07-30
- RR 3.5.0 released · 2018-04-23
Package metadata
- First published
- 2018-07-30
- Total releases
- 4 / 8 yrs
- License
- GPL-2 OSI
- Download size
- 19 KB
- Installed size
- not tracked yet
- With dependencies
- not tracked yet
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