R Observatory: Metrics for pmrm version 0.0.4

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

pmrm

0.0.4

Progression Models for Repeated Measures

0packages depend

3.2Kdownloads / year

100.0%test coverage

13/13checks pass

Overview

About

Maintained by William Michael LandauFirst published 2026-01-303 releasesCRAN page ↗GitHub ↗

A progression model for repeated measures (PMRM) is a continuous-time nonlinear mixed-effects model for longitudinal clinical trials in progressive diseases. Unlike mixed models for repeated measures (MMRMs), which estimate treatment effects as linear combinations of additive effects on the outcome scale, PMRMs characterize treatment effects in terms of the underlying disease trajectory. This framing yields clinically interpretable quantities such as average time saved and percent reduction in decline due to treatment. This package implements frequentist PMRMs by Raket (2022) doi:10.1002/sim.9581 using 'RTMB' by Kristensen (2016) doi:10.18637/jss.v070.i05.

Install

R (CRAN)pak (dev)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("pmrm", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

if (!requireNamespace("pak", quietly = TRUE))
  install.packages("pak", repos = "https://cloud.r-project.org/")
pak::pak("openpharma/pmrm")

Development version from openpharma/pmrm. Installs pak first if it is not already available.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-pmrm

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-pmrm

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-pmrm

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed).

Health

CRAN checks

13OK

Slowest check: 6.3 min · r-release-macos-x86_64

Code health

Yes

Tests · ratio 0.70

100.0%

Coverage · measured lines

100%

Documentation · exports

12

Dependencies · direct

Check history

OK2026-08-05
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
NOTE2026-08-01
12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
OK2026-07-22
13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE
ERROR2026-04-25
11 OK · 0 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE
OK2026-03-10
14 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE

Documentation

READMEYes · 366 wordsVignettesYes · dynamicpkgdown siteNoNEWSYes · 100% structuredCode of conductNoContributing guideNo

Examples that run: 100%
Documented parameters: 74%
Return-value docs: 91%
References docs: 0%

Downloads

3.2K

CRAN downloads in the past year

Rank #8,852 · ~9/day · ~265/mo

Releases R versions

Daily download trend is not available in this view yet.

16730 days

1K90 days

3.2K1 year

Compare downloads with other packages →

Also on60 r2u21 autocran

Repository

GitHub ↗ openpharma/pmrm

6Stars

2Forks

3Open issues

0Open PRs

4Releases

69Commits

1Contributors

disease-progression-modelmmrmrrtmbtmbadcomppmrm

69 commits · Last activity 2026-04-03 · 0% stars, 30d

Stars over time

2026-01-22 · 12026-07-07 · 6

Repository practices

Upstream repositoryBeta

4 development-tooling and community-health practices detected across 3 families in the upstream repository

Checks run against github.com/openpharma/pmrm on 2026-08-16.

Continuous integration (1)

GitHub Actions

Docs source (1)

README.Rmd

Lint, format, editor (2)

lintrRStudio project

How this is detected·Detection ruleset v1 (2026-07-18)

Dependencies

Declared dependencies

14 external dependencies (excludes base and recommended)

Depends (1)

R >= 3.5.0

Imports (12)

dplyr generics ggplot2MatrixnlmeRTMB rlangstatstibble tidyselectutilsvctrs

LinkingTo (0)

none

Suggests (6)

knitr markdown rmarkdown readr scales testthat (>= 3.0.0)

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

Code & Tests

People & History

People (4)

Maintainer (1)

William Michael Landau

Author, Maintainer

Authors (3)

William Michael Landau

Author, Maintainer

Kasper Kristensen

Author

Lars Lau Raket

Author

Copyright holders (1)

Eli Lilly and Company

Copyright holder, Funder

Funders (1)

Eli Lilly and Company

Copyright holder, Funder

Listed in earlier versions (2)

Landau

no longer listed · 0.0.2 to 0.0.4

Raket

no longer listed · 0.0.2 to 0.0.4

Package Timeline

3 releases. Pick two to compare their code metrics. R releases are shown for context.

R
R 4.6.0 released · 2026-04-24
0.0.4Latest
2026-04-04 · current release · diff ↗
0.0.3
2026-03-13 · diff ↗
0.0.2
2026-03-10
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2026-01-30
Total releases: 3 / 1 yrs
License: MIT + file LICENSE OSI
Minimum R: ≥ 3.5.0
Download size: 1.7 MB
Installed size: not tracked yet
With dependencies: not tracked yet

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("pmrm")

Format

Landau, W. M., Eli Lilly and Company, , Kristensen, K., & Raket, L. L. (2026). pmrm: Progression Models for Repeated Measures (Version 0.0.4) [Computer software]. https://doi.org/10.32614/CRAN.package.pmrm

This is what citation() produces when a package has no citation file of its own. If it prints something else, use that.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for pmrm version 0.0.4 [Data set]. HJJB, LLC. Data release v2026-08-18. https://doi.org/10.5281/zenodo.21843040

From data release v2026-08-18, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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