R Observatory: Metrics for pipe.design version 0.5.1

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

This package was removed from CRAN on 2026-04-30. Its history is shown below.

Reason: email to the maintainer is undeliverable

Details below reflect version 0.5.1, its last release before removal.

pipe.design

0.5.1Package record

Dual-Agent Dose Escalation for Phase I Trials using the PIPE Design

0packages depend

1.1Kdownloads / year

–test coverage

–flavors OK

Overview

About

Maintained by Michael SweetingCRAN page ↗

Implements the Product of Independent beta Probabilities dose Escalation (PIPE) design for dual-agent Phase I trials as described in Mander AP, Sweeting MJ (2015) DOI:10.1002/sim.6434.

Changes in 0.5.1

** Corrected error that was returned if constraint argument was left as NULL

** Updated print.pipe.sim to return more information regarding percentage of doses recommended for Phase II

** Corrected error where "nodiag" constraint option still allowed dose combinations in which both drugs were escalated simultaneously to be admissible - thanks to Dr Graham Wheeler for reporting this issue.

** Changed pipe.design so that random number list is updated even if data are encountered for the kth cohort. This then gives same operating behaviour for a single simulated trial and one where part of the data are pre-specified. Thanks for Simon Kirby (Pfizer) for spotting this unwanted behaviour.

** All of pipe.design's constraints and the non.admissible option have now been addedd to ShinyPIPE

** print.pipe.sim now also returns the percentage of times a trial recommends 0,1,2,.... doses for Phase II experimentation.

From NEWS in the release

Install

R (source archive)

url <- "https://cran.r-project.org/src/contrib/Archive/pipe.design/pipe.design_0.5.1.tar.gz"
pkgFile <- "pipe.design_0.5.1.tar.gz"
download.file(url, pkgFile)
install.packages(pkgFile, type = "source", repos = NULL)

This package is no longer on CRAN, so install.packages() cannot fetch it by name. This downloads the last archived source (0.5.1) and builds it locally. Install its dependencies first, and note that building from source needs the usual compiler toolchain.

Health

CRAN checks

CRAN check results are not tracked yet.

Status changes

NOTE12 OK, 2 NOTE2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 0.5.1

READMENoVignettesNoNEWSYes · 100% structured · mentions 0.5.1Citation fileNoWebsitenot declared in DESCRIPTION

Help pages: 4
Examples that run: 100%1 run in a plain check
Exported functions with examples: 50%
Documented parameters: 91%
Return-value docs: 50%
Help pages citing references: 100%

How these are measured

Downloads

1.1K

CRAN downloads in the past year

Rank #25,731 · ~3/day · ~91/mo

Releases R versions

Daily download trend is not available in this view yet.

030 days

090 days

1.1K1 year

Compare downloads with other packages →

Also on67 r2u2 autocran122 c2d4u

How downloads are counted

Dependencies

Declared dependencies

4 external dependencies (excludes base and recommended)

Depends (0)

none

Imports (3)

ggplot2 gtools xtable

LinkingTo (0)

none

Suggests (1)

shiny

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

–indirect (not tracked)

Nothing depends on this yet.

How these are counted

Code & Tests

People & History

People (1)

Michael Sweeting

Contributor

Maintainer since 0.1 (2015)

Releases (6)

Pick two releases to compare their code metrics.

archivedRemoved from CRAN
2026-04-30
email to the maintainer is undeliverable
R
R 4.6.0 released · 2026-04-24
R
R 4.5.0 released · 2025-04-11
R
R 4.4.0 released · 2024-04-24
R
R 4.3.0 released · 2023-04-21
R
R 4.2.0 released · 2022-04-22
R
R 4.1.0 released · 2021-05-18
R
R 4.0.0 released · 2020-04-24
R
R 3.6.0 released · 2019-04-26
R
R 3.5.0 released · 2018-04-23
0.5.1
record
2017-06-16 · diff ↗
0.5
record
2017-05-01 · diff ↗
R
R 3.4.0 released · 2017-04-21
0.4
record
2016-05-10 · diff ↗ ·
added 1 export
runShinyPIPE
R
R 3.3.0 released · 2016-05-03
0.3
record
2015-07-24 · diff ↗

Show 4 earlier eventsHide 4 earlier events

0.2
record
2015-05-12 · diff ↗
R
R 3.2.0 released · 2015-04-16
0.1
record
2015-03-19
R
R 3.1.0 released · 2014-04-10

Package metadata

First published: 2015-03-19
Total releases: 6 / 11 yrs
License: GPL (>= 2) OSI
Download size: 56 KB

Appears in task views

Design of Experiments (DoE) & Analysis of Experimental Data

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("pipe.design")

Format

Sweeting, M. (n.d.). pipe.design: Dual-Agent Dose Escalation for Phase I Trials using the PIPE Design (Version 0.5.1) [Computer software]. Retrieved October 26, 2026, from https://CRAN.R-project.org/package=pipe.design

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for pipe.design version 0.5.1 [Data set]. HJJB, LLC. Data release v2026-10-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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