phase1RMD
Repeated Measurement Design for Phase I Clinical Trial
Description
Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
Downloads
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Last 90 days
2.6K
Last year
Trend: +97.2% (30d vs prior 30d)
0
Last 30 days
23
Last 90 days
93
Last year
Trend: -100% (30d vs prior 30d)
4
Last 7 days
10
Last 30 days
0
All-time
autoCRAN-only: this name is served only by autoCRAN, so the count is exact.
CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
email = "vivien.jyin@gmail.com"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
email = "vivien.jyin@gmail.com"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
Check History
NOTE 11 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 8, 2026
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
WARNING 11 OK · 1 NOTE · 1 WARNING · 0 ERROR · 0 FAILURE Jun 7, 2026
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
Code & tests
Open call graph →Code intelligence has not been computed for this package yet.
Code
Structure
Lines of code
7,170
Files
43
Compiled share
0%
Has compiled src
No
Language breakdown
API
Exported functions
8
Internal functions
31
Recent export changes
Testing & CI
Has tests
No
Test-to-code ratio
0.00
testthat edition
–
CI present
No
CI type
[]
PR gated
No
Docs
Return-value doc rate
100%
\dontrun example ratio
0%
Roxygen coverage
100%
Has pkgdown
No
NEWS present
No
Health & Security signals
Informational signals; not verdicts.
on.exit coverage
0%
Unsafe pattern score
0
Dep constraint coverage
0%
Secret pattern count
0
Bundled 3rd-party code
2 items
Portability & License
Min R version
3.0.0
System requirements
–
C++ standard
–
License
GPL (>= 2)
License flags
SPDX valid, OSI approved
History
Versions
4
First release
2017-03-23
Latest release
2020-03-11
Avg cadence
216 days
Cold removal rate
100%
Dep drift
2
LOC over versions
Per-file churn detail lives in the source pipeline: https://github.com/r-observatory/cran-code-metrics.