phase1RMD
Repeated Measurement Design for Phase I Clinical Trial
Description
Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
Downloads
209
Last 30 days
21785th
652
Last 90 days
2.6K
Last year
Trend: -8.3% (30d vs prior 30d)
CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
email = "vivien.jyin@gmail.com"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
email = "vivien.jyin@gmail.com"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Jun Yin <vivien.jyin@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jun",
family = "Yin",
role = c("aut", "cre"),
...[truncated]...
"),
person(given = "Yu",
family = "Du",
role = "aut"),
person(given = "Sumithra",
family = "Mandrekar",
role = "aut"))
as necessary.