phase1PRMD
Personalized Repeated Measurement Design for Phase I Clinical Trials
Description
Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Lu Zhang <luzhangstat@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Lu",
family = "Zhang",
role = c("aut", "cre"),
email = "luzhangstat@gmail.com"),
person(given = "Jun",
family = "Yin",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Lu Zhang <luzhangstat@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Lu",
family = "Zhang",
role = c("aut", "cre"),
email = "luzhangstat@gmail.com"),
person(given = "Jun",
family = "Yin",
role = "aut"))
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Lu Zhang <luzhangstat@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Lu",
family = "Zhang",
role = c("aut", "cre"),
email = "luzhangstat@gmail.com"),
person(given = "Jun",
family = "Yin",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Lu Zhang <luzhangstat@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Lu",
family = "Zhang",
role = c("aut", "cre"),
email = "luzhangstat@gmail.com"),
person(given = "Jun",
family = "Yin",
role = "aut"))
as necessary.