Personalized Repeated Measurement Design for Phase I Clinical Trials
Overview
Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) doi:10.1002/sim.7134.
Major changes
Remove the dependence on package phase1RMD
From NEWS.md in the release
Install
Health
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Lu Zhang <luzhangstat@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Lu",
family = "Zhang",
role = c("aut", "cre"),
email = "luzhangstat@gmail.com"),
person(given = "Jun",
family = "Yin",
role = "aut"))
as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 16
- Examples that run
- 60%6 run in a plain check · 4 hold no code
- Exported functions with examples
- 86%
- Documented parameters
- 98%
- Return-value docs
- 86%
- Help pages citing references
- 0%
Downloads
Dependencies
Code & Tests
Datasets
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- 1.0.2Latest
- RR 3.6.0 released · 2019-04-26
- 1.0.12019-02-03
- RR 3.5.0 released · 2018-04-23
Package metadata
- First published
- 2019-02-03
- Total releases
- 2 / 7 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 3.0.0
- Bundled data
- 22 KB / 3 files
- Download size
- 65 KB
Cite
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Run in R for the authors' preferred citation:
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