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ordcrm

1.0.0Package record

Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs

0packages depend
2.1Kdownloads / year
–test coverage
11/13flavors OK

Overview

About

Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose finding trial and performs simulations to assess design performance under various scenarios. 3 dose finding designs are included in this package: ordinal proportional odds model (POM) CRM, ordinal continuation ratio (CR) model CRM, and the binary 2-parameter logistic model CRM. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous dose levels, combining ordinal grades 0 and 1 into one category, and incorporate safety and/or stopping rules. For POM and CR model designs, ordinal toxicity grades are specified by common terminology criteria for adverse events (CTCAE) version 4.0. Function 'pseudodata' creates the necessary starting models for these 3 designs, and function 'nextdose' estimates the next dose to test in a cohort of patients for a target DLT rate. We also provide the function 'crmsimulations' to assess the performance of these 3 dose finding designs under various scenarios.

Install

Health

CRAN checks
2NOTE11OK
Check messages
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’

No Authors@R field in DESCRIPTION.
Please add one, modifying
  Authors@R: c(person(given = c("Emily", "V."),
                      family = "Dressler",
                      role = c("aut", "cre"),
                      email = "emilyvdressler@gmail.com"),
               person(given = c("PhD", "Zhengyan"),
                      family = "Huang",
                      role = "aut"))
as necessary.

CRAN check page ↗

Slowest check: 1.5 min · r-oldrel-windows-x86_64
Status changes
  • NOTE11 OK, 2 NOTE2026-06-09
  • ERROR11 OK, 1 NOTE, 1 ERROR2026-06-08
  • NOTE9 OK, 5 NOTE2026-03-10
Advisories

none known

Documentation

In release 1.0.0
READMEYes · 165 wordsVignettesNoNEWSYes · 0% structured · mentions 1.0.0Citation fileNoWebsitenot declared in DESCRIPTION
Help pages
3
Examples that run
100%3 run in a plain check
Exported functions with examples
100%
Documented parameters
97%
Return-value docs
100%
Help pages citing references
100%

Downloads

2.1K
CRAN downloads in the past year
Rank #23,110 · ~6/day · ~173/mo
Daily download trend is not available in this view yet.
19230 days
57390 days
2.1K1 year
Compare downloads with other packages →
Also on68 r2u3 autocran

Dependencies

Declared dependencies
1 external dependency (excludes base and recommended)

Installing ordcrm adds 61 packages (32 with compiled code, 66 MB of source tarballs). Heaviest: stringi 11 MB, TH.data 8.2 MB, ggplot2 6.0 MB.

Depends (3)
R >= 3.3.1statsgraphics
Imports (1)
LinkingTo (0)
none
Suggests (0)
none
Enhances (0)
none
Reverse dependencies
0direct
0indirect

Nothing depends on this yet.

People & History

People (from the free-text Author field) (2)

Maintainer since 1.0.0 (2016)

Releases (1)
  • R
    R 4.6.0 released · 2026-04-24
  • R
    R 4.5.0 released · 2025-04-11
  • R
    R 4.4.0 released · 2024-04-24
  • R
    R 4.3.0 released · 2023-04-21
  • R
    R 4.2.0 released · 2022-04-22
  • R
    R 4.1.0 released · 2021-05-18
  • R
    R 4.0.0 released · 2020-04-24
  • R
    R 3.6.0 released · 2019-04-26
  • R
    R 3.5.0 released · 2018-04-23
  • R
    R 3.4.0 released · 2017-04-21
  • 1.0.0Latest
    2016-11-04 · current release
  • R
    R 3.3.0 released · 2016-05-03

Package metadata

First published
2016-11-04
Total releases
1 / 10 yrs
License
GPL (>= 2) OSI
Minimum R
≥ 3.3.1
Download size
35 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("ordcrm")

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

APA

Balamuta, J. J. (2026). R Observatory: Metrics for ordcrm version 1.0.0 [Data set]. HJJB, LLC. Data release v2026-10-26. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-26, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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