ordcrm
Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs
Description
Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose finding trial and performs simulations to assess design performance under various scenarios. 3 dose finding designs are included in this package: ordinal proportional odds model (POM) CRM, ordinal continuation ratio (CR) model CRM, and the binary 2-parameter logistic model CRM. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous dose levels, combining ordinal grades 0 and 1 into one category, and incorporate safety and/or stopping rules. For POM and CR model designs, ordinal toxicity grades are specified by common terminology criteria for adverse events (CTCAE) version 4.0. Function 'pseudodata' creates the necessary starting models for these 3 designs, and function 'nextdose' estimates the next dose to test in a cohort of patients for a target DLT rate. We also provide the function 'crmsimulations' to assess the performance of these 3 dose finding designs under various scenarios.
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24
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90
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Trend: -100% (30d vs prior 30d)
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CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
Check History
NOTE 11 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
ERROR 11 OK · 1 NOTE · 0 WARNING · 1 ERROR · 0 FAILURE Jun 8, 2026
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
NOTE 9 OK · 5 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
CRAN incoming feasibility
Maintainer: ‘Emily V. Dressler <EmilyVDressler@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = c("Emily", "V."),
family = "Dressler",
role = c("aut", "cre"),
email = "emilyvdressler@gmail.com"),
person(given = c("PhD", "Zhengyan"),
family = "Huang",
role = "aut"))
as necessary.
LazyData
'LazyData' is specified without a 'data' directory
LazyData
'LazyData' is specified without a 'data' directory
LazyData
'LazyData' is specified without a 'data' directory
Code
Structure
Lines of code
3,795
Files
13
Compiled share
0%
Has compiled src
No
Language breakdown
API
Exported functions
3
Internal functions
0
Recent export changes
Testing & CI
Has tests
No
Test-to-code ratio
0.00
testthat edition
–
CI present
No
CI type
[]
PR gated
No
Docs
Return-value doc rate
100%
\dontrun example ratio
0%
Roxygen coverage
100%
Has pkgdown
No
NEWS present
Yes
Health & Security signals
Informational signals; not verdicts.
on.exit coverage
–
Unsafe pattern score
0
Dep constraint coverage
0%
Secret pattern count
0
Bundled 3rd-party code
2 items
Portability & License
Min R version
3.3.1
System requirements
–
C++ standard
–
License
GPL (>= 2)
License flags
SPDX valid, OSI approved
History
Versions
1
First release
2016-11-04
Latest release
2016-11-04
Avg cadence
–
Cold removal rate
–
Dep drift
0
Per-file churn detail lives in the source pipeline: https://github.com/r-observatory/cran-code-metrics.
Dependency Network
Version History
1 trackedR Observatory began tracking this package on Mar 10, 2026; it first appeared on CRAN Nov 4, 2016. Releases before tracking aren’t shown.