Bayesian Methods for Optimal Threshold Estimation
Overview
Functions to estimate the optimal threshold of diagnostic markers or treatment selection markers. The optimal threshold is the marker value that maximizes the utility of the marker based-strategy (for diagnostic or treatment selection) in a given population. The utility function depends on the type of marker (diagnostic or treatment selection), but always takes into account the preferences of the patients or the physician in the decision process. For estimating the optimal threshold, ones must specify the distributions of the marker in different groups (defined according to the type of marker, diagnostic or treatment selection) and provides data to estimate the parameters of these distributions. Ones must also provide some features of the target populations (disease prevalence or treatment efficacies) as well as the preferences of patients or physicians. The functions rely on Bayesian inference which helps producing several indicators derived from the optimal threshold. See Blangero, Y, Rabilloud, M, Ecochard, R, and Subtil, F (2019) doi:10.1177/0962280218821394 for the original article that describes the estimation method for treatment selection markers and Subtil, F, and Rabilloud, M (2019) doi:10.1002/bimj.200900242 for diagnostic markers.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-10
Documentation
- Help pages
- 41 (1 internal)includes a package overview page
- Examples that run
- 100%6 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
Downloads
Dependencies
Installing optimalThreshold adds 4 packages (2 with compiled code, 187 KB of source tarballs). Heaviest: rjags 75 KB, coda 73 KB, HDInterval 29 KB.
Code & Tests
People & History
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- 1.0Latest2020-01-13 · current release
- RR 3.6.0 released · 2019-04-26
Package metadata
- First published
- 2020-01-13
- Total releases
- 1 / 6 yrs
- License
- GPL (>= 2.0)
- Minimum R
- ≥ 3.1.2
- Download size
- 59 KB
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