A Meta-Analysis Approach with Filtering for Identifying Gene-Level Gene-Environment Interactions with Genetic Association Data
Overview
Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) doi:10.1002/gepi.22115. It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.
Install
Health
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Jiebiao Wang <randel.wang@gmail.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: c(person(given = "Jiebiao",
family = "Wang",
role = c("aut", "cre"),
email = "randel.wang@gmail.com"),
person(given = "Qianying",
family = "Liu",
role = "aut"),
person(given = c("Lin", "S."),
family = "Chen",
role = "aut"))
as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 3
- Examples that run
- 100%3 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 33%
Downloads
Repository
Stars over time
1 development-tooling and community-health practice detected across 1 family in the upstream repository
Checks run against github.com/randel/ofgem on 2026-10-22.
Dependencies
Installing ofGEM adds 5 packages (3 with compiled code, 2.2 MB of source tarballs). Heaviest: forestplot 1.9 MB, checkmate 247 KB, backports 29 KB.
Code & Tests
Datasets
People & History
Maintainer since 1.0 (2018)
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- 1.0Latest2018-07-13 · current release
- RR 3.5.0 released · 2018-04-23
Package metadata
- First published
- 2018-07-13
- Total releases
- 1 / 8 yrs
- License
- GPL
- Bundled data
- 5.1 KB / 1 file
- Download size
- 11 KB
Cite
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