nmw
Understanding Nonlinear Mixed Effects Modeling for Population Pharmacokinetics
Description
This shows how 'NONMEM' (Beal SL, Sheiner LB, Boeckmann AJ, Bauer RJ. NONMEM 7.5 Users Guides. Icon plc, 2020) software works. 'NONMEM' classical estimation methods such as 'First Order (FO) approximation', 'First Order Conditional Estimation (FOCE)', and 'Laplacian approximation' are explained. Functions are also provided for post-run processing of NONMEM output files, generating PDF diagnostic reports including objective function value analysis, parameter estimates, prediction and residual diagnostics, empirical Bayes estimate (EBE) analysis, input data summary, and individual pharmacokinetic parameter distributions. Helper utilities for building NONMEM-ready datasets from SDTM-style source tables are also included.
Downloads
405
Last 30 days
9981st
1.4K
Last 90 days
4K
Last year
Trend: +1% (30d vs prior 30d)
16
Last 30 days
49
Last 90 days
115
Last year
Trend: -30.4% (30d vs prior 30d)
1
Last 7 days
8
Last 30 days
0
All-time
autoCRAN-only: this name is served only by autoCRAN, so the count is exact.
CRAN Check Status
Show all 13 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check History
OK 13 OK · 0 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 9, 2026
NOTE 12 OK · 1 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Jun 8, 2026
CRAN incoming feasibility
Maintainer: ‘Kyun-Seop Bae <k@acr.kr>’ Reading Rd files failed with message: cannot open the connection