Bayesian Platform Design with Subgroup Efficacy Exploration(MIDAS-2)
Overview
The rapid screening of effective and optimal therapies from large numbers of candidate combinations, as well as exploring subgroup efficacy, remains challenging, which necessitates innovative, integrated, and efficient trial designs(Yuan, Y., et al. (2016) doi:10.1002/sim.6971). MIDAS-2 package enables quick and continuous screening of promising combination strategies and exploration of their subgroup effects within a unified platform design framework. We used a regression model to characterize the efficacy pattern in subgroups. Information borrowing was applied through Bayesian hierarchical model to improve trial efficiency considering the limited sample size in subgroups(Cunanan, K. M., et al. (2019) doi:10.1177/1740774518812779). MIDAS-2 provides an adaptive drug screening and subgroup exploring framework to accelerate immunotherapy development in an efficient, accurate, and integrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi: 10.1177/1740774517692302>).
Install
Health
NOTECRAN incoming feasibilityr-devel-linux-x86_64-debian-clang, r-devel-linux-x86_64-debian-gcc
Maintainer: ‘Su Liwen <cpusullivan@163.com>’
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Authors@R: person(given = "Su",
family = "Liwen",
role = c("aut", "cre"),
email = "cpusullivan@163.com")
as necessary.- NOTE11 OK, 2 NOTENow
- NOTE12 OK, 2 NOTE2026-03-10
Documentation
- Help pages
- 2
- Examples that run
- 100%2 run in a plain check
- Exported functions with examples
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- Documented parameters
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- Return-value docs
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- Help pages citing references
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Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- 1.1.0Latest2023-07-14 · current release · diff ↗ ·
removed 2 exports
pattern:^[[:alpha:]]+, hc_platformadded 2 exports
platform_midas2, platform_midas2s - RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- 0.1.02021-12-16
- RR 4.1.0 released · 2021-05-18
Package metadata
- First published
- 2021-12-16
- Total releases
- 2 / 5 yrs
- License
- GPL-3 OSI
- Download size
- 7.5 KB
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