midas2
Bayesian Platform Design with Subgroup Efficacy Exploration(MIDAS-2)
Description
The rapid screening of effective and optimal therapies from large numbers of candidate combinations, as well as exploring subgroup efficacy, remains challenging, which necessitates innovative, integrated, and efficient trial designs(Yuan, Y., et al. (2016) <doi:10.1002/sim.6971>). MIDAS-2 package enables quick and continuous screening of promising combination strategies and exploration of their subgroup effects within a unified platform design framework. We used a regression model to characterize the efficacy pattern in subgroups. Information borrowing was applied through Bayesian hierarchical model to improve trial efficiency considering the limited sample size in subgroups(Cunanan, K. M., et al. (2019) <doi:10.1177/1740774518812779>). MIDAS-2 provides an adaptive drug screening and subgroup exploring framework to accelerate immunotherapy development in an efficient, accurate, and integrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi: 10.1177/1740774517692302>).
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | NOTE |
| r-devel-linux-x86_64-debian-gcc | NOTE |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | OK |
| r-oldrel-macos-x86_64 | OK |
| r-oldrel-windows-x86_64 | OK |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (2 non-OK)
CRAN incoming feasibility
Maintainer: ‘Su Liwen <cpusullivan@163.com>’
No Authors@R field in DESCRIPTION.
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Authors@R: person(given = "Su",
family = "Liwen",
role = c("aut", "cre"),
email = "cpusullivan@163.com")
as necessary.
CRAN incoming feasibility
Maintainer: ‘Su Liwen <cpusullivan@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Su",
family = "Liwen",
role = c("aut", "cre"),
email = "cpusullivan@163.com")
as necessary.
Check History
NOTE 12 OK · 2 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
CRAN incoming feasibility
Maintainer: ‘Su Liwen <cpusullivan@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Su",
family = "Liwen",
role = c("aut", "cre"),
email = "cpusullivan@163.com")
as necessary.
CRAN incoming feasibility
Maintainer: ‘Su Liwen <cpusullivan@163.com>’
No Authors@R field in DESCRIPTION.
Please add one, modifying
Authors@R: person(given = "Su",
family = "Liwen",
role = c("aut", "cre"),
email = "cpusullivan@163.com")
as necessary.