Integrated Discovery of Oncogenic Signatures
Overview
A method to integrate molecular profiles of cancer patients (gene copy number and mRNA abundance) to identify candidate gain of function alterations. These candidate alterations can be subsequently further tested to discover cancer driver alterations. Briefly, this method tests of genomic correlates of mRNA dysregulation and prioritise those where DNA gains/amplifications are associated with elevated mRNA expression of the same gene. For details see, Haider S et al. (2016) "Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia", Genome Biology, https://pubmed.ncbi.nlm.nih.gov/27358048/.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-10
Documentation
- Help pages
- 9
- Examples that run
- 100%9 run in a plain check
- Exported functions with examples
- 100%
- Documented parameters
- not tracked
- Return-value docs
- not tracked
- Help pages citing references
- 0%
Downloads
Dependencies
Installing iDOS adds 5 packages (0 with compiled code, 228 KB of source tarballs). Heaviest: formatR 94 KB, VennDiagram 81 KB, lambda.r 25 KB.
Code & Tests
People & History
Pick two releases to compare their code metrics.
- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- unarchivedReturned to CRAN2024-03-11
- 1.0.1Latest
- archivedRemoved from CRAN2023-08-18email to the maintainer is undeliverable
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
- RR 4.0.0 released · 2020-04-24
- RR 3.6.0 released · 2019-04-26
- RR 3.5.0 released · 2018-04-23
- RR 3.4.0 released · 2017-04-21
- 1.0.02016-07-27
- RR 3.3.0 released · 2016-05-03
Package metadata
- First published
- 2016-07-27
- Total releases
- 2 / 10 yrs
- License
- GPL-2 OSI
- Minimum R
- ≥ 3.6.0
- Download size
- 29 KB
Cite
Cite this package
Run in R for the authors' preferred citation:
citation("iDOS")This package has no citation file, so citation() returns this entry built from DESCRIPTION.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.