High-Throughput Toxicokinetics Examples
Overview
High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (doi:10.18637/jss.v079.i04) and Breen et al. (2021) (doi:10.1080/17425255.2021.1935867). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (doi:10.1371/journal.pone.0321321), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.
Initial public (CRAN) release (October 6, 2025)
This package is intended to reduce the check time and size of the primary package for HTTK.
It can be accessed from within httk using the command httk::httk.vignettes()
From NEWS.md in the release
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK12 OK2026-04-25
- NOTE11 OK, 3 NOTE2026-03-10
Documentation
- Help pages
- 35 (1 internal)includes a package overview page
- Examples that run
- no examples
- Exported functions with examples
- not tracked
- Documented parameters
- not tracked
- Return-value docs
- not tracked
- Help pages citing references
- 94% with a bibliography file
- a) Pearce (2017): HTTK Basics HTML
- b) Ring (2017) HTTK-Pop: Generating subpopulations HTML
- c) Pearce (2017): Evaluation of Tissue Partitioning HTML
- d) Wambaugh (2018): Evaluating In Vitro-In Vivo Extrapolation HTML
- e) Frank (2018): Neuronal Network IVIVE HTML
- f) Honda (2019): Updated Armitage et al. (2014) Model HTML
- g) Wambaugh (2019): Uncertainty Monte Carlo HTML
- h) Linakis (2020): High Throughput Inhalation Model HTML
- i) Kapraun (2022): Human Gestational Model HTML
- j) Truong (2025) Full Human Gestational IVIVE HTML
Show 3 moreHide 3 vignettes
Downloads
Dependencies
Installing httkexamples adds 63 packages (37 with compiled code, 54 MB of source tarballs). Heaviest: ggplot2 6.0 MB, data.table 5.7 MB, bslib 5.6 MB.
Code & Tests
Datasets
People & History
- RR 4.6.0 released · 2026-04-24
- 0.0.1Latest2025-12-10 · current release
- RR 4.5.0 released · 2025-04-11
Package metadata
- First published
- 2025-12-10
- Total releases
- 1 / 1 yrs
- License
- MIT + file LICENSE OSI
- Minimum R
- ≥ 2.10
- Bundled data
- 1.3 MB / 11 files
- Download size
- 2.3 MB
Cite
Cite this package
Run in R for the authors' entry:
citation("httkexamples")The package provides a citation file, so citation() returns the authors' own entry.
It points to 10.18637/jss.v079.i04.
Cite the R Observatory
For a number measured here: a download total, a coverage figure, an archival date.
From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.