Calculation of Covariance Between Markers for Half-Sib Families
Overview
The theoretical covariance between pairs of markers is calculated from either paternal haplotypes and maternal linkage disequilibrium (LD) or vise versa. A genetic map is required. Grouping of markers is based on the correlation matrix and a representative marker is suggested for each group. Employing the correlation matrix, optimal sample size can be derived for association studies based on a SNP-BLUP approach. The implementation relies on paternal half-sib families and biallelic markers. If maternal half-sib families are used, the roles of sire/dam are swapped. Multiple families can be considered. Wittenburg, Bonk, Doschoris, Reyer (2020) "Design of Experiments for Fine-Mapping Quantitative Trait Loci in Livestock Populations" doi:10.1186/s12863-020-00871-1. Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004) "Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium" doi:10.1086/381000.
Install
Health
- OK13 OK2026-08-05
- NOTE12 OK, 1 NOTE2026-08-01
- OK14 OK2026-03-30
- ERROR13 OK, 1 ERROR2026-03-10
Documentation
- Help pages
- 19
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- Exported functions with examples
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- Documented parameters
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- Return-value docs
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- Help pages citing references
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Installing hscovar adds 8 packages (4 with compiled code, 8.2 MB of source tarballs). Heaviest: data.table 5.7 MB, jsonlite 1.0 MB, XML 937 KB.
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- RR 4.6.0 released · 2026-04-24
- RR 4.5.0 released · 2025-04-11
- RR 4.4.0 released · 2024-04-24
- RR 4.3.0 released · 2023-04-21
- RR 4.2.0 released · 2022-04-22
- RR 4.1.0 released · 2021-05-18
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- RR 4.0.0 released · 2020-04-24
- 0.2.12020-04-16 · diff ↗ ·
added 8 exports
AR1, calcvar, coeff.beta.k, pwr.normtest, pwr.snpblup, search.best.n.bisection, simpleM, startvalue - 0.1.22020-03-04
- RR 3.6.0 released · 2019-04-26
Package metadata
- First published
- 2020-03-04
- Total releases
- 4 / 6 yrs
- License
- GPL (>= 2) OSI
- Minimum R
- ≥ 3.5.0
- Bundled data
- 143 KB / 1 file
- Download size
- 179 KB
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