Calculate Genetic Interactions for Paired CRISPR Targets
Overview
Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the 'gimap' package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) doi:10.1016/j.celrep.2021.109597.
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Documentation
- Help pages
- 41 (6 internal)
- Examples that run
- 8%2 run in a plain check · 22 never run
- Exported functions with examples
- 80%
- Documented parameters
- 100%
- Return-value docs
- 100%
- Help pages citing references
- 0%
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- 96%
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- 101
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- 1.1.3Latest
- RR 4.6.0 released · 2026-04-24
- unarchivedReturned to CRAN2026-02-05
- 1.1.22026-02-05 · diff ↗ ·
removed 2 exports
save_example_data_timepoint, save_example_data_treatmentadded 2 exports
save_example_timepoint_data, save_example_treatment_data - archivedRemoved from CRAN2025-12-03policy violation On Internet access
- 1.1.12025-04-30 · diff ↗ ·
removed 1 export
plot_targets_baradded 3 exports
plot_targets, save_example_data_timepoint, save_example_data_treatment - RR 4.5.0 released · 2025-04-11
- 1.0.3
- 1.0.22025-02-19 · diff ↗
- 1.0.12025-02-03
- RR 4.4.0 released · 2024-04-24
Package metadata
- First published
- 2025-02-03
- Total releases
- 6 / 1 yrs
- License
- BSD_3_clause + file LICENSE OSI · relicensed from GPL-3 in 1.1.3
- Minimum R
- ≥ 3.5.0
- Download size
- 7.7 MB
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Cite this package
Run in R for the authors' entry:
citation("gimap")The package provides a citation file, so citation() returns the authors' own entry.
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