crmPack
Object-Oriented Implementation of Dose Escalation Designs
Description
Implements a wide range of dose escalation designs. The focus is on model-based designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy to setup a new design with custom JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules. Further details are presented in Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.
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CRAN Check Status
Show all 14 flavors
| Flavor | Status |
|---|---|
| r-devel-linux-x86_64-debian-clang | OK |
| r-devel-linux-x86_64-debian-gcc | OK |
| r-devel-linux-x86_64-fedora-clang | OK |
| r-devel-linux-x86_64-fedora-gcc | OK |
| r-devel-macos-arm64 | OK |
| r-devel-windows-x86_64 | OK |
| r-oldrel-macos-arm64 | NOTE |
| r-oldrel-macos-x86_64 | NOTE |
| r-oldrel-windows-x86_64 | NOTE |
| r-patched-linux-x86_64 | OK |
| r-release-linux-x86_64 | OK |
| r-release-macos-arm64 | OK |
| r-release-macos-x86_64 | OK |
| r-release-windows-x86_64 | OK |
Check details (3 non-OK)
installed package size
installed size is 8.5Mb
sub-directories of 1Mb or more:
R 2.0Mb
doc 4.2Mb
help 1.3Mb
installed package size
installed size is 9.4Mb
sub-directories of 1Mb or more:
R 2.0Mb
doc 4.2Mb
help 2.2Mb
installed package size
installed size is 8.1Mb
sub-directories of 1Mb or more:
R 1.6Mb
doc 4.2Mb
help 1.3Mb
Check History
NOTE 11 OK · 3 NOTE · 0 WARNING · 0 ERROR · 0 FAILURE Mar 10, 2026
installed package size
installed size is 8.5Mb
sub-directories of 1Mb or more:
R 2.0Mb
doc 4.2Mb
help 1.3Mb
installed package size
installed size is 9.4Mb
sub-directories of 1Mb or more:
R 2.0Mb
doc 4.2Mb
help 2.2Mb
installed package size
installed size is 8.1Mb
sub-directories of 1Mb or more:
R 1.6Mb
doc 4.2Mb
help 1.3Mb