R Observatory: Metrics for cobenrich version 1.0.1

Balamuta, James Joseph

doi:10.5281/zenodo.21843040

cobenrich

1.0.1Package record

Using Multiple Continuous Biomarkers for Patient Enrichment in Two-Stage Clinical Designs

0packages depend

1.9Kdownloads / year

–test coverage

13/13flavors OK

Overview

About

Maintained by Jiangtao GouCRAN page ↗

Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers. See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.

Install

R (CRAN)Ubuntu (r2u)Fedora (COPR)openSUSE (OBS)

install.packages("cobenrich", repos = "https://cloud.r-project.org/")

Installs the current CRAN release. Prebuilt binaries on Windows and macOS.

Release

# enable cranapt (r2u) if it is not already set up, then install
grep -rqs r2u.stat.illinois.edu /etc/apt/sources.list /etc/apt/sources.list.d/ \
  || curl -fsSL https://raw.githubusercontent.com/eddelbuettel/r2u/master/inst/scripts/add_cranapt_noble.sh | sudo bash
sudo apt install -y r-cran-cobenrich

Fast Ubuntu binaries via r2u (no compilation). The cranapt setup runs once and is skipped when it is already enabled. We list this channel from recorded r2u download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

bspm (used by r2u) also needs make: sudo apt install make

# enable the iucar/cran COPR if it is not already present, then install
ls /etc/yum.repos.d/*iucar*cran*.repo >/dev/null 2>&1 \
  || sudo dnf copr enable -y iucar/cran
sudo dnf install -y R-CRAN-cobenrich

RPMs from the iucar/cran COPR, rebuilt from CRAN.

For install.packages() integration in R, also: sudo dnf install R-CoprManager

# add the autoCRAN OBS repo (Tumbleweed) if it is missing, then install
zypper -q lr | grep -qi autoCRAN \
  || sudo zypper addrepo https://download.opensuse.org/repositories/devel:/languages:/R:/autoCRAN/openSUSE_Tumbleweed/devel:languages:R:autoCRAN.repo
sudo zypper install -y R-cobenrich

RPMs auto-built from CRAN on openSUSE OBS (Tumbleweed). We list this channel from recorded autoCRAN download activity rather than from a live index of the repository, so treat it as last known rather than guaranteed.

Health

CRAN checks

13OK

CRAN check page ↗

Slowest check: 50 s · r-devel-windows-x86_64

Status changes

OK13 OK2026-08-05
NOTE12 OK, 1 NOTE2026-08-01
OK14 OK2026-03-10

Advisories

none known

How this is measured·How advisories are found

Documentation

In release 1.0.1

READMENoVignettesNoNEWSNoCitation fileNoWebsitenot declared in DESCRIPTION

Help pages: 5
Examples that run: 100%3 run in a plain check
Exported functions with examples: 60%
Documented parameters: not tracked
Return-value docs: not tracked
Help pages citing references: 60%

How these are measured

Downloads

1.9K

CRAN downloads in the past year

Rank #22,993 · ~5/day · ~160/mo

Releases R versions

Daily download trend is not available in this view yet.

17330 days

57590 days

1.9K1 year

Compare downloads with other packages →

Also on80 r2u4 autocran

How downloads are counted

Dependencies

Declared dependencies

1 external dependency (excludes base and recommended)

Installing cobenrich adds 5 packages (4 with compiled code, 4.1 MB of source tarballs). Heaviest: sandwich 1.4 MB, mvtnorm 1.0 MB, gmm 919 KB.

Depends (1)

R >= 4.2.0

Imports (2)

tmvtnormstats

LinkingTo (0)

none

Suggests (0)

none

Enhances (0)

none

Dependency license breakdown →

Reverse dependencies

0direct

0indirect

Nothing depends on this yet.

How these are counted

Code & Tests

People & History

People (2)

Jiangtao Gou

Author, Maintainer since 1.0.1 (2025)

Fengqing (Zoe) Zhang

Author

Releases (1)

R
R 4.6.0 released · 2026-04-24
1.0.1Latest
record
2025-04-15 · current release
R
R 4.5.0 released · 2025-04-11

Package metadata

First published: 2025-04-15
Total releases: 1 / 1 yrs
License: GPL-3 OSI
Minimum R: ≥ 4.2.0
Download size: 3.6 KB

Cite

Cite this package

Run in R for the authors' preferred citation:

citation("cobenrich")

Format

Gou, J., & Zhang, F. (. (2025). cobenrich: Using Multiple Continuous Biomarkers for Patient Enrichment in Two-Stage Clinical Designs (Version 1.0.1) [Computer software]. https://doi.org/10.32614/CRAN.package.cobenrich

This package has no citation file, so citation() returns this entry built from DESCRIPTION.

Cite the R Observatory

For a number measured here: a download total, a coverage figure, an archival date.

Format

APA

Balamuta, J. J. (2026). R Observatory: Metrics for cobenrich version 1.0.1 [Data set]. HJJB, LLC. Data release v2026-10-25. https://doi.org/10.5281/zenodo.21843040

From data release v2026-10-25, which the citation names so these numbers can be found later. More on citing and the projects behind them.

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